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Glod4 Gene Detail
Summary
  • Symbol
    Glod4
  • Name
    glyoxalase domain containing 4
  • Synonyms
    1700082G03Rik, 2700085E05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914451
    NCBI Gene: 67201
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76111221-76134525 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    584 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914451
 protein coding gene Chr11:76011813-76134551 (-)
129S1/SvImJ ENSMUSG00200046553
 protein coding gene Chr11:73242871-73266436 (-)
A/J ENSMUSG00195036741
 protein coding gene Chr11:73121319-73144891 (-)
AKR/J ENSMUSG00220046015
 protein coding gene Chr11:73336542-73360107 (-)
BALB/cJ ENSMUSG00180039140
 protein coding gene Chr11:73309777-73333342 (-)
C3H/HeJ ENSMUSG00175033712
 protein coding gene Chr11:73279672-73303240 (-)
C57BL/6NJ ENSMUSG00215039630
 protein coding gene Chr11:72887501-72911986 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016754
 protein coding gene Chr11:71066378-71186780 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210041037
 protein coding gene Chr11:73098120-73121685 (-)
DBA/2J ENSMUSG00185035588
 protein coding gene Chr11:73368128-73391693 (-)
FVB/NJ ENSMUSG00205039189
 protein coding gene Chr11:73204749-73228312 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230046258
 protein coding gene Chr11:74398717-74422287 (-)
NOD/ShiLtJ ENSMUSG00190046060
 protein coding gene Chr11:73415018-73438574 (-)
NZO/HlLtJ ENSMUSG00225038119
 protein coding gene Chr11:76558272-76581820 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GLOD4, glyoxalase domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLOD4, glyoxalase domain containing 4
  • Synonyms
    C17orf25, CGI-150, HC6, HC71
  • Links
    NCBI Gene ID: 51031
    UniProt: Q9HC38

  • Chr Location
    17p13.3; chr17:757097-785895 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotype references
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    13
  • Targeted
    3
  • Genomic Mutations
    2 involving Glod4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    31 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    18
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67201 NCBI Gene Model | MGI Sequence Detail 23305 C57BL/6J ±  kb
transcript NM_001362901 RefSeq | MGI Sequence Detail 3084 C57BL/6  
polypeptide Q9CPV4 UniProt | EBI | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000032784 glyoxalase domain-containing protein 4
    (term hierarchy)
  • InterPro Domains
    IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
    IPR043193 Glyoxalase domain-containing protein 4
    IPR043194 Glyoxalase domain-containing protein 4, C-terminal
    IPR059155 Glyoxalase domain-containing protein 4 domain
    IPR037523 Vicinal oxygen chelate (VOC), core domain
  • GlyGen
    Q9CPV4 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923867, MGI:2144668
References
more
  • Summaries
    All 40
    Gene Ontology 2
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:387040 Wright S, et al., Selective peroxynitrite-mediated protein nitration catalyzed by glyoxalase domain containing protein 4. Proc Natl Acad Sci U S A. 2026 Feb 10;123(6):e2515002123
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory