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Fgf22 Gene Detail
Summary
  • Symbol
    Fgf22
  • Name
    fibroblast growth factor 22
  • Synonyms
    2210414E06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914362
    NCBI Gene: 67112
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79590887-79593629 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914362
 protein coding gene Chr10:79590887-79594430 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017457
 protein coding gene Chr10:80297194-80299036 (+)
A/J MGP_AJ_G0017435
 protein coding gene Chr10:77508775-77510617 (+)
AKR/J MGP_AKRJ_G0017396
 protein coding gene Chr10:79616174-79618016 (+)
BALB/cJ MGP_BALBcJ_G0017397
 protein coding gene Chr10:77734473-77736315 (+)
C3H/HeJ MGP_C3HHeJ_G0017220
 protein coding gene Chr10:79723936-79725778 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017851
 protein coding gene Chr10:83072265-83074107 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015539
 protein coding gene Chr10:73733497-73735309 (+)
CAST/EiJ MGP_CASTEiJ_G0016787
 protein coding gene Chr10:79896258-79898064 (+)
CBA/J MGP_CBAJ_G0017192
 protein coding gene Chr10:86296220-86298062 (+)
DBA/2J MGP_DBA2J_G0017298
 protein coding gene Chr10:76723512-76725354 (+)
FVB/NJ MGP_FVBNJ_G0017292
 protein coding gene Chr10:75888223-75890065 (+)
LP/J MGP_LPJ_G0017369
 protein coding gene Chr10:80779732-80781574 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017318
 protein coding gene Chr10:88276139-88277981 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017892
 protein coding gene Chr10:79591677-79593519 (+)
PWK/PhJ MGP_PWKPhJ_G0016568
 protein coding gene Chr10:76582297-76584103 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016357
 protein coding gene Chr10:78568192-78569997 (+)
WSB/EiJ MGP_WSBEiJ_G0016847
 protein coding gene Chr10:79623417-79625259 (+)



Homology
more
  • Human Ortholog
    FGF22, fibroblast growth factor 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF22, fibroblast growth factor 22
  • Links
    NCBI Gene ID: 27006
    neXtProt AC: NX_Q9HCT0
    UniProt: Q9HCT0

  • Chr Location
    19p13.3; chr19:639879-644373 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired vesicle clustering in glutamatergic synapses, decreased miniature excitatory postsynaptic currents, enhanced paired-pulse facilitation, increased synaptic depression, and decreased susceptibility topentylenetetrazol-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    928
  • Tissues
    189
  • cDNA Data
    10
  • Literature Summary
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67112 NCBI Gene Model | MGI Sequence Detail 2743 C57BL/6J ±  kb
transcript NM_023304 RefSeq | MGI Sequence Detail 1060 C57BL/6  
polypeptide Q9ESS2 UniProt | EBI | MGI Sequence Detail 162 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 11
    Primer pair 3
    Other 3

    Microarray probesets 3
References
more
  • Summaries
    All 68
    Developmental Gene Expression 20
    Gene Ontology 3
    Phenotypes 25
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:295180 Terauchi A, et al., Neuronal fibroblast growth factor 22 signaling during development, but not in adults, is involved in anhedonia. Neuroreport. 2020 Jan 27;31(2):125-130
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory