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Higd2a Gene Detail
Summary
  • Symbol
    Higd2a
  • Name
    HIG1 domain family, member 2A
  • Synonyms
    2010110M21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914294
    NCBI Gene: 67044
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:54738044-54738960 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 28.84 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914294
 protein coding gene Chr13:54738020-54738971 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020573
 protein coding gene Chr13:53996491-53997442 (+)
A/J MGP_AJ_G0020527
 protein coding gene Chr13:52015213-52016164 (+)
AKR/J MGP_AKRJ_G0020505
 protein coding gene Chr13:53543913-53544864 (+)
BALB/cJ MGP_BALBcJ_G0020523
 protein coding gene Chr13:52247182-52248133 (+)
C3H/HeJ MGP_C3HHeJ_G0020322
 protein coding gene Chr13:53369303-53370254 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020957
 protein coding gene Chr13:55651126-55652077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018539
 protein coding gene Chr13:50010182-50011135 (+)
CAST/EiJ MGP_CASTEiJ_G0019836
 protein coding gene Chr13:53448612-53449556 (+)
CBA/J MGP_CBAJ_G0020282
 protein coding gene Chr13:57764141-57765092 (+)
DBA/2J MGP_DBA2J_G0020405
 protein coding gene Chr13:51583793-51584744 (+)
FVB/NJ MGP_FVBNJ_G0020384
 protein coding gene Chr13:51031628-51032579 (+)
LP/J MGP_LPJ_G0020481
 protein coding gene Chr13:54271407-54272358 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020413
 protein coding gene Chr13:57259930-57260881 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021000
 protein coding gene Chr13:53139115-53140066 (+)
PWK/PhJ MGP_PWKPhJ_G0019592
 protein coding gene Chr13:51569708-51571272 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019419
 protein coding gene Chr13:52054255-52055202 (+)
WSB/EiJ MGP_WSBEiJ_G0019898
 protein coding gene Chr13:53476917-53477868 (+)



Homology
more
  • Human Ortholog
    HIGD2A, HIG1 hypoxia inducible domain family member 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIGD2A, HIG1 hypoxia inducible domain family member 2A
  • Synonyms
    RCF1b
  • Links
    NCBI Gene ID: 192286
    neXtProt AC: NX_Q9BW72
    UniProt: Q9BW72

  • Chr Location
    5q35.2; chr5:176388751-176389761 (+)  GRCh38
  • Human Ortholog
    HIGD2B, HIG1 hypoxia inducible domain family member 2B
  • Synonyms
    HIGD2BP
  • Links
    NCBI Gene ID: 123346
    UniProt: Q4VC39

  • Chr Location
    15q24.1; chr15:72675798-72686182 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    45
  • cDNA Data
    117
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67044 NCBI Gene Model | MGI Sequence Detail 917 C57BL/6J ±  kb
    transcript NM_025933 RefSeq | MGI Sequence Detail 613 C57BL/6  
    polypeptide Q9CQJ1 UniProt | EBI | MGI Sequence Detail 106 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 118

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145173
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:297830 Salazar C, et al., Biosystem Analysis of the Hypoxia Inducible Domain Family Member 2A: Implications in Cancer Biology. Genes (Basel). 2020 Feb 18;11(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory