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Syap1 Gene Detail
Summary
  • Symbol
    Syap1
  • Name
    synapse associated protein 1
  • Synonyms
    2010110O17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914293
    NCBI Gene: 67043
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:161640053-161671443 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 75.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914293
 protein coding gene ChrX:161639839-161671458 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036242
 protein coding gene ChrX:160885622-160918479 (-)
A/J MGP_AJ_G0036212
 protein coding gene ChrX:160091984-160124336 (-)
AKR/J MGP_AKRJ_G0036140
 protein coding gene ChrX:165204201-165238231 (-)
BALB/cJ MGP_BALBcJ_G0036205
 protein coding gene ChrX:158087209-158126138 (-)
C3H/HeJ MGP_C3HHeJ_G0035911
 protein coding gene ChrX:161248903-161280067 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036727
 protein coding gene ChrX:165621564-165652892 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033549
 protein coding gene ChrX:151178345-151210468 (-)
CAST/EiJ MGP_CASTEiJ_G0035200
 protein coding gene ChrX:140228374-140263258 (-)
CBA/J MGP_CBAJ_G0035886
 protein coding gene ChrX:170374427-170410370 (-)
DBA/2J MGP_DBA2J_G0036052
 protein coding gene ChrX:158992408-159026184 (-)
FVB/NJ MGP_FVBNJ_G0035983
 protein coding gene ChrX:158133344-158164920 (-)
LP/J MGP_LPJ_G0036137
 protein coding gene ChrX:162062547-162093545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036015
 protein coding gene ChrX:179066948-179101615 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036768
 protein coding gene ChrX:160385244-160420048 (-)
PWK/PhJ MGP_PWKPhJ_G0034898
 protein coding gene ChrX:137040574-137072943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034719
 protein coding gene ChrX:140697206-140728650 (-)
WSB/EiJ MGP_WSBEiJ_G0035335
 protein coding gene ChrX:158363262-158394438 (-)



Homology
more
  • Human Ortholog
    SYAP1, synapse associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYAP1, synapse associated protein 1
  • Synonyms
    BSTA, PRO3113
  • Links
    NCBI Gene ID: 94056
    neXtProt AC: NX_Q96A49
    UniProt: Q96A49

  • Chr Location
    Xp22.2; chrX:16719612-16765340 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5. Mice hemizygous or homozygous for a knock-out allele are viable and fertile with no overt defects in adult brain morphology and cultured motoneuron survival or axon growth. Hemizygous KO males display reduced advanced locomotor skills.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    16
  • cDNA Data
    131
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031357 Ensembl Gene Model | MGI Sequence Detail 31391 C57BL/6J ±  kb
transcript ENSMUST00000033723 Ensembl | MGI Sequence Detail 2087 Not Applicable  
polypeptide ENSMUSP00000033723 Ensembl | MGI Sequence Detail 365 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 131
    cDNA 131

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147985
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:276465 R von Collenberg C, et al., An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance. Biol Open. 2019 Jun 5;8(6):bio042366
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory