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Acad8 Gene Detail
Summary
  • Symbol
    Acad8
  • Name
    acyl-Coenzyme A dehydrogenase family, member 8
  • Synonyms
    2310016C19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914198
    NCBI Gene: 66948
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:26885431-26910862 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 12.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914198
 protein coding gene Chr9:26885431-26910872 (-)
129S1/SvImJ ENSMUSG00200007712
 protein coding gene Chr9:23872705-23899259 (-)
A/J ENSMUSG00195005800
 protein coding gene Chr9:23680238-23706734 (-)
AKR/J ENSMUSG00220010176
 protein coding gene Chr9:23678164-23704663 (-)
BALB/cJ ENSMUSG00180006617
 protein coding gene Chr9:23814402-23840897 (-)
C3H/HeJ ENSMUSG00175019297
 protein coding gene Chr9:23790841-23817334 (-)
C57BL/6NJ ENSMUSG00215006242
 protein coding gene Chr9:23776193-23802691 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031923
 protein coding gene Chr9:22812911-22835024 (-)
CAST/EiJ ENSTCUG00005018513
 protein coding gene Chr9:23767850-23794310 (-)
CBA/J ENSMUSG00210022089
 protein coding gene Chr9:23832857-23859410 (-)
DBA/2J ENSMUSG00185002456
 protein coding gene Chr9:23872910-23899405 (-)
FVB/NJ ENSMUSG00205003990
 protein coding gene Chr9:24161567-24188142 (-)
JF1/MsJ ENSUMUG00000010225
 protein coding gene Chr9:24003893-24030536 (-)
LP/J ENSMUSG00230005173
 protein coding gene Chr9:24278619-24305184 (-)
NOD/ShiLtJ ENSMUSG00190006058
 protein coding gene Chr9:23864828-23891396 (-)
NZO/HlLtJ ENSMUSG00225014724
 protein coding gene Chr9:24291750-24318303 (-)
PWK/PhJ ENSLUMG00010009130
 protein coding gene Chr9:23897217-23923822 (-)
SPRET/EiJ ENSMSPG00010001962
 protein coding gene Chr9:24190234-24217075 (-)
WSB/EiJ ENSIUOG00005015250
 protein coding gene Chr9:23342884-23369625 (-)



Homology
more
  • Human Ortholog
    ACAD8, acyl-CoA dehydrogenase family member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACAD8, acyl-CoA dehydrogenase family member 8
  • Synonyms
    ACAD-8, ARC42, IBDH
  • Links
    NCBI Gene ID: 27034
    UniProt: Q9UKU7

  • Chr Location
    11q25; chr11:134253514-134265855 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit cold intolerance at young age with a progressive hepatic steatosis and abnormal mitochondria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    97
  • cDNA Data
    14
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031969 Ensembl Gene Model | MGI Sequence Detail 25432 C57BL/6J ±  kb
    transcript ENSMUST00000120367 Ensembl | MGI Sequence Detail 2885 Not Applicable  
    polypeptide ENSMUSP00000112908 Ensembl | MGI Sequence Detail 413 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000003598 isobutyryl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.5
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR006091 Acyl-CoA dehydrogenase/oxidase, middle domain
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
      IPR034178 Isobutyryl-CoA dehydrogenase
      IPR052547 Mitochondrial Isobutyryl-CoA Dehydrogenase
    • GlyGen
      Q9D7B6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143118
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 8
    • Earliest
      J:383012 Andresen BS, et al., Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for distinct acyl-CoA dehydrogenases in isoleucine and valine metabolism. Am J Hum Genet. 2000 Nov;67(5):1095-103
    • Latest
      J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory