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Trmt6 Gene Detail
Summary
  • Symbol
    Trmt6
  • Name
    tRNA methyltransferase 6
  • Synonyms
    3300001M20Rik, mKIAA1153
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914176
    NCBI Gene: 66926
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:132646127-132657975 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    413 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914176
 protein coding gene Chr2:132646127-132658127 (-)
129S1/SvImJ ENSMUSG00200046468
 protein coding gene Chr2:129697111-129710324 (-)
A/J ENSMUSG00195027931
 protein coding gene Chr2:129722854-129736066 (-)
AKR/J ENSMUSG00220044273
 protein coding gene Chr2:129495200-129508410 (-)
BALB/cJ ENSMUSG00180045633
 protein coding gene Chr2:129541413-129554629 (-)
C3H/HeJ ENSMUSG00175042491
 protein coding gene Chr2:130083800-130097012 (-)
C57BL/6NJ ENSMUSG00215023255
 protein coding gene Chr2:129570791-129584001 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024344
 protein coding gene Chr2:125588822-125600865 (-)
CAST/EiJ ENSTCUG00005038730
 protein coding gene Chr2:128853517-128865802 (-)
CBA/J ENSMUSG00210030796
 protein coding gene Chr2:129940257-129953471 (-)
DBA/2J ENSMUSG00185034729
 protein coding gene Chr2:129582647-129595859 (-)
FVB/NJ ENSMUSG00205033664
 protein coding gene Chr2:128756868-128770082 (-)
JF1/MsJ ENSUMUG00000010115
 protein coding gene Chr2:129400340-129413566 (-)
LP/J ENSMUSG00230037978
 protein coding gene Chr2:131333310-131346518 (-)
NOD/ShiLtJ ENSMUSG00190013253
 protein coding gene Chr2:129663859-129677073 (-)
NZO/HlLtJ ENSMUSG00225027239
 protein coding gene Chr2:139241783-139254997 (-)
PWK/PhJ ENSLUMG00010040873
 protein coding gene Chr2:129404362-129417584 (-)
SPRET/EiJ ENSMSPG00010025275
 protein coding gene Chr2:131776674-131788710 (-)
WSB/EiJ ENSIUOG00005040927
 protein coding gene Chr2:129511460-129524681 (-)



Homology
more
  • Human Ortholog
    TRMT6, tRNA methyltransferase 6 non-catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRMT6, tRNA methyltransferase 6 non-catalytic subunit
  • Synonyms
    CGI-09, GCD10, Gcd10p, TRM6
  • Links
    NCBI Gene ID: 51605
    UniProt: Q9UJA5

  • Chr Location
    20p12.3; chr20:5937228-5950558 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased CD4+ T cells and stimulated T cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    645
  • Tissues
    7
  • cDNA Data
    90
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037376 Ensembl Gene Model | MGI Sequence Detail 11849 C57BL/6J ±  kb
transcript ENSMUST00000039554 Ensembl | MGI Sequence Detail 2828 Not Applicable  
polypeptide ENSMUSP00000044687 Ensembl | MGI Sequence Detail 497 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016683 tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6
    (term hierarchy)
  • InterPro Domains
    IPR017423 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Molecular
Reagents
less
  • All nucleic 90
    cDNA 90

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139161, MGI:2139353
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:361247 Zuo H, et al., tRNA m(1)A modification regulate HSC maintenance and self-renewal via mTORC1 signaling. Nat Commun. 2024 Jul 8;15(1):5706
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory