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Rnf128 Gene Detail
Summary
  • Symbol
    Rnf128
  • Name
    ring finger protein 128
  • Synonyms
    1300002C13Rik, GRAIL, Greul1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914139
    NCBI Gene: 66889
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:138464089-138573894 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 61.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2325 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914139
 protein coding gene ChrX:138464065-138573894 (+)
129S1/SvImJ ENSMUSG00200045412
 protein coding gene ChrX:117467797-117577663 (+)
A/J ENSMUSG00195044497
 protein coding gene ChrX:121326790-121436637 (+)
AKR/J ENSMUSG00220035288
 protein coding gene ChrX:114778716-114888556 (+)
BALB/cJ ENSMUSG00180034401
 protein coding gene ChrX:117759503-117869343 (+)
C3H/HeJ ENSMUSG00175031257
 protein coding gene ChrX:121627919-121737807 (+)
C57BL/6NJ ENSMUSG00215043759
 protein coding gene ChrX:118172276-118282110 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033442
 protein coding gene ChrX:128210165-128316116 (+)
CAST/EiJ ENSTCUG00005039457
 protein coding gene ChrX:118822696-118932052 (+)
CBA/J ENSMUSG00210038005
 protein coding gene ChrX:118555546-118665439 (+)
DBA/2J ENSMUSG00185028285
 protein coding gene ChrX:132446474-132556372 (+)
FVB/NJ ENSMUSG00205027524
 protein coding gene ChrX:116953881-117063732 (+)
JF1/MsJ ENSUMUG00000029948
 protein coding gene ChrX:151684235-151796307 (+)
LP/J ENSMUSG00230039262
 protein coding gene ChrX:139068797-139178635 (+)
NOD/ShiLtJ ENSMUSG00190037945
 protein coding gene ChrX:117963524-118073356 (+)
NZO/HlLtJ ENSMUSG00225041821
 protein coding gene ChrX:143757999-143868846 (+)
PWK/PhJ ENSLUMG00010043250
 protein coding gene ChrX:116446171-116558254 (+)
SPRET/EiJ ENSMSPG00010036296
 protein coding gene ChrX:121064330-121174936 (+)
WSB/EiJ ENSIUOG00005037339
 protein coding gene ChrX:118634673-118744593 (+)



Homology
more
  • Human Ortholog
    RNF128, ring finger protein 128
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF128, ring finger protein 128
  • Synonyms
    GRAIL
  • Links
    NCBI Gene ID: 79589
    UniProt: Q8TEB7

  • Chr Location
    Xq22.3; chrX:106693794-106797016 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele dsiplay defects in naive, helper and anergic T cell states affecting survival, proliferation and cytokine secretion. Homozygotes for another null allele show impaired T cell tolerance and regulatory T cell function and increased susceptibility to autoimmune disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    164
  • cDNA Data
    93
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66889 NCBI Gene Model | MGI Sequence Detail 109806 C57BL/6J ±  kb
    transcript NM_023270 RefSeq | MGI Sequence Detail 2764 C57BL/6  
    polypeptide Q9D304 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 93
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147939
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:377177 Ran X, et al., RNF128 deficiency in macrophages promotes colonic inflammation by suppressing the autophagic degradation of S100A8. Cell Death Dis. 2025 Jan 15;16(1):20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory