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Kcng4 Gene Detail
Summary
  • Symbol
    Kcng4
  • Name
    potassium voltage-gated channel, subfamily G, member 4
  • Synonyms
    4921535I01Rik, KV6.3, KV6.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913983
    NCBI Gene: 66733
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:120350593-120362419 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 68.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    472 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913983
 protein coding gene Chr8:120350593-120362497 (-)
129S1/SvImJ ENSMUSG00200040417
 protein coding gene Chr8:114690758-114702584 (-)
A/J ENSMUSG00195024425
 protein coding gene Chr8:114975722-114987548 (-)
AKR/J ENSMUSG00220041646
 protein coding gene Chr8:115166074-115177900 (-)
BALB/cJ ENSMUSG00180022977
 protein coding gene Chr8:115021575-115033402 (-)
C3H/HeJ ENSMUSG00175026786
 protein coding gene Chr8:115078049-115089871 (-)
C57BL/6NJ ENSMUSG00215030594
 protein coding gene Chr8:114651817-114663642 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031625
 protein coding gene Chr8:110794998-110806008 (-)
CAST/EiJ ENSTCUG00005031429
 protein coding gene Chr8:114391518-114406421 (-)
CBA/J ENSMUSG00210034897
 protein coding gene Chr8:115005408-115017233 (-)
DBA/2J ENSMUSG00185016366
 protein coding gene Chr8:121109360-121121186 (-)
FVB/NJ ENSMUSG00205025255
 protein coding gene Chr8:113986255-113998077 (-)
JF1/MsJ ENSUMUG00000017080
 protein coding gene Chr8:123401939-123413761 (-)
LP/J ENSMUSG00230023931
 protein coding gene Chr8:124744116-124755942 (-)
NOD/ShiLtJ ENSMUSG00190017566
 protein coding gene Chr8:115119883-115131709 (-)
NZO/HlLtJ ENSMUSG00225041578
 protein coding gene Chr8:128110103-128121929 (-)
PWK/PhJ ENSLUMG00010038705
 protein coding gene Chr8:114826011-114837857 (-)
SPRET/EiJ ENSMSPG00010037984
 protein coding gene Chr8:117021200-117032776 (-)
WSB/EiJ ENSIUOG00005026032
 protein coding gene Chr8:115824496-115836279 (-)



Homology
more
  • Human Ortholog
    KCNG4, potassium voltage-gated channel modifier subfamily G member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNG4, potassium voltage-gated channel modifier subfamily G member 4
  • Synonyms
    KV6.3, KV6.4
  • Links
    NCBI Gene ID: 93107
    UniProt: Q8TDN1

  • Chr Location
    16q24.1; chr16:84218657-84240012 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility and oligoasthenoteratozoospermia associated with defects in spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    15
  • cDNA Data
    8
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045246 Ensembl Gene Model | MGI Sequence Detail 11827 C57BL/6J ±  kb
    transcript ENSMUST00000061828 Ensembl | MGI Sequence Detail 3806 Not Applicable  
    polypeptide ENSMUSP00000056552 Ensembl | MGI Sequence Detail 506 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000000789 voltage-gated potassium channel subfamily G member 4
      (term hierarchy)
    • InterPro Domains
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003971 Potassium channel, voltage dependent, Kv5/Kv9
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028325 Voltage-gated potassium channel
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142750
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 48
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:390366 Daly KM, et al., M4-ipRGCs regulate contrast sensitivity in vision. Cell Rep. 2026 Jul 5;45(7):117662
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory