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Tab3 Gene Detail
Summary
  • Symbol
    Tab3
  • Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 3
  • Synonyms
    4921526G09Rik, Map3k7ip3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913974
    NCBI Gene: 66724
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:84617628-84678075 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 39.32 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1229 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913974
 protein coding gene ChrX:84617466-84678075 (+)
129S1/SvImJ ENSMUSG00200032083
 protein coding gene ChrX:66623738-66684187 (+)
A/J ENSMUSG00195040848
 protein coding gene ChrX:70345356-70405807 (+)
AKR/J ENSMUSG00220027566
 protein coding gene ChrX:65232601-65293052 (+)
BALB/cJ ENSMUSG00180023969
 protein coding gene ChrX:66890295-66950748 (+)
C3H/HeJ ENSMUSG00175030083
 protein coding gene ChrX:70512243-70572694 (+)
C57BL/6NJ ENSMUSG00215013676
 protein coding gene ChrX:67046154-67106605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033216
 protein coding gene ChrX:80655562-80717712 (+)
CAST/EiJ ENSTCUG00005037516
 protein coding gene ChrX:68097532-68157261 (+)
CBA/J ENSMUSG00210025423
 protein coding gene ChrX:67234600-67295048 (+)
DBA/2J ENSMUSG00185037099
 protein coding gene ChrX:79583613-79644062 (+)
FVB/NJ ENSMUSG00205018350
 protein coding gene ChrX:66531113-66591566 (+)
JF1/MsJ ENSUMUG00000023876
 protein coding gene ChrX:100291726-100351142 (+)
LP/J ENSMUSG00230010162
 protein coding gene ChrX:86230563-86291012 (+)
NOD/ShiLtJ ENSMUSG00190024018
 protein coding gene ChrX:66539403-66599848 (+)
NZO/HlLtJ ENSMUSG00225045585
 protein coding gene ChrX:91363643-91424091 (+)
PWK/PhJ ENSLUMG00010033465
 protein coding gene ChrX:66018405-66077672 (+)
SPRET/EiJ ENSMSPG00010022163
 protein coding gene ChrX:69720317-69783603 (+)
WSB/EiJ ENSIUOG00005042063
 protein coding gene ChrX:67114070-67174500 (+)



Homology
more
  • Human Ortholog
    TAB3, TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAB3, TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  • Synonyms
    MAP3K7IP3, NAP1
  • Links
    NCBI Gene ID: 257397
    UniProt: Q8N5C8

  • Chr Location
    Xp21.2; chrX:30827442-30975084 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    14 images
    15 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    611
  • Tissues
    14
  • cDNA Data
    43
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035476 Ensembl Gene Model | MGI Sequence Detail 60448 C57BL/6J ±  kb
transcript ENSMUST00000048250 Ensembl | MGI Sequence Detail 6364 Not Applicable  
polypeptide ENSMUSP00000039668 Ensembl | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 51
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:360487 Ali T, et al., TAK1-binding protein 2 (TAB2) and TAB3 are redundantly required for TLR-induced cytokine production in macrophages. Int Immunol. 2024 Aug 13;36(9):439-450
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory