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Ntmt1 Gene Detail
Summary
  • Symbol
    Ntmt1
  • Name
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
  • Synonyms
    2610205E22Rik, Mettl11a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913867
    NCBI Gene: 66617
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30697838-30713045 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913867
protein coding gene Chr2:30697576-30713045 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025573
protein coding gene Chr2:29085493-29101398 (+)
A/J MGP_AJ_G0025551
protein coding gene Chr2:27906519-27924218 (+)
AKR/J MGP_AKRJ_G0025520
protein coding gene Chr2:28857945-28875977 (+)
BALB/cJ MGP_BALBcJ_G0025547
protein coding gene Chr2:28044055-28059987 (+)
C3H/HeJ MGP_C3HHeJ_G0025308
protein coding gene Chr2:28782637-28799352 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025992
protein coding gene Chr2:30037951-30056984 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023400
protein coding gene Chr2:26674755-26689998 (+)
CAST/EiJ MGP_CASTEiJ_G0024770
protein coding gene Chr2:28706176-28724688 (+)
CBA/J MGP_CBAJ_G0025285
protein coding gene Chr2:31082475-31104164 (+)
DBA/2J MGP_DBA2J_G0025418
protein coding gene Chr2:27689643-27705078 (+)
FVB/NJ MGP_FVBNJ_G0025381
protein coding gene Chr2:27521807-27537935 (+)
LP/J MGP_LPJ_G0025504
protein coding gene Chr2:28994829-29012577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025411
protein coding gene Chr2:30885406-30901202 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026050
protein coding gene Chr2:28768821-28784223 (+)
PWK/PhJ MGP_PWKPhJ_G0024517
protein coding gene Chr2:27551739-27567557 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024317
protein coding gene Chr2:28901062-28917863 (+)
WSB/EiJ MGP_WSBEiJ_G0024838
protein coding gene Chr2:28931787-28951136 (+)



Homology
more
  • Human Ortholog
    NTMT1, N-terminal Xaa-Pro-Lys N-methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTMT1, N-terminal Xaa-Pro-Lys N-methyltransferase 1
  • Synonyms
    AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NRMT1, NTM1A
  • Links
    NCBI Gene ID: 28989
    neXtProt AC: NX_Q9BV86
    UniProt: Q9BV86

  • Chr Location
    9q34.11; chr9:129608872-129636135 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit preweaning lethality and premature death associated with premature aging, decreased body size and weight, skin thinning, liver degeneration, increased sensitivity to oxidative stress and female infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026857 Ensembl Gene Model | MGI Sequence Detail 15208 C57BL/6J ±  kb
    transcript ENSMUST00000041830 Ensembl | MGI Sequence Detail 1387 Not Applicable  
    polypeptide ENSMUSP00000035303 Ensembl | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 53

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139140, MGI:2145326
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:317829 Wang F, et al., Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Sci Adv. 2022 Jan 7;8(1):eabg5369

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory