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Psmd6 Gene Detail
Summary
  • Symbol
    Psmd6
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
  • Synonyms
    2400006A19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913663
    NCBI Gene: 66413
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:8348818-8357578 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913663
 protein coding gene Chr14:8348779-8357589 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021006
 protein coding gene Chr14:6637797-6646516 (-)
A/J MGP_AJ_G0020954
 protein coding gene Chr14:6488847-6497603 (-)
AKR/J MGP_AKRJ_G0020931
 protein coding gene Chr14:6580375-6589131 (-)
BALB/cJ MGP_BALBcJ_G0020957
 protein coding gene Chr14:6494151-6502906 (-)
C3H/HeJ MGP_C3HHeJ_G0020741
 protein coding gene Chr14:6681263-6689982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021390
 protein coding gene Chr14:6826952-6835752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018959
 protein coding gene Chr14:7125777-7134980 (-)
CAST/EiJ MGP_CASTEiJ_G0020263
 protein coding gene Chr14:6666038-6675079 (-)
CBA/J MGP_CBAJ_G0020707
 protein coding gene Chr14:7074122-7082841 (-)
DBA/2J MGP_DBA2J_G0020830
 protein coding gene Chr14:6402754-6411471 (-)
FVB/NJ MGP_FVBNJ_G0020812
 protein coding gene Chr14:6335130-6343930 (-)
LP/J MGP_LPJ_G0020906
 protein coding gene Chr14:6660860-6669579 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020838
 protein coding gene Chr14:7120321-7129121 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021423
 protein coding gene Chr14:6552998-6561754 (-)
PWK/PhJ MGP_PWKPhJ_G0020015
 protein coding gene Chr14:6400076-6408794 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019835
 protein coding gene Chr14:6646989-6656784 (-)
WSB/EiJ MGP_WSBEiJ_G0020321
 protein coding gene Chr14:6582489-6591244 (-)



Homology
more
  • Human Ortholog
    PSMD6, proteasome 26S subunit, non-ATPase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD6, proteasome 26S subunit, non-ATPase 6
  • Synonyms
    p42A, p44S10, Rpn7, S10, SGA-113M
  • Links
    NCBI Gene ID: 9861
    neXtProt AC: NX_Q15008
    UniProt: Q15008

  • Chr Location
    3p14.1; chr3:64010550-64024010 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    128
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66413 NCBI Gene Model | MGI Sequence Detail 8761 C57BL/6J ±  kb
transcript NM_025550 RefSeq | MGI Sequence Detail 1337 C57BL/6  
polypeptide Q99JI4 UniProt | EBI | MGI Sequence Detail 389 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000002182 26S proteasome non-ATPase regulatory subunit 6
    (term hierarchy)
  • InterPro Domains
    IPR019585 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
    IPR045135 26S proteasome regulatory subunit Rpn7, N-terminal
    IPR049549 26S proteasome regulatory subunit RPN7/PSMD6, C-terminal helix
    IPR000717 Proteasome component (PCI) domain
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR036390 Winged helix DNA-binding domain superfamily
Molecular
Reagents
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  • All nucleic 129
    cDNA 128
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:113917 Ren S, et al., The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma. Oncogene. 2000 Mar 9;19(11):1419-27
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory