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Asf1a Gene Detail
Summary
  • Symbol
    Asf1a
  • Name
    anti-silencing function 1A histone chaperone
  • Synonyms
    2310079C17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913653
    NCBI Gene: 66403
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:53473057-53485321 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 27.24 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913653
 protein coding gene Chr10:53472853-53485321 (+)
129S1/SvImJ ENSMUSG00200024936
 protein coding gene Chr10:50370204-50382672 (+)
A/J ENSMUSG00195027891
 protein coding gene Chr10:50638184-50650652 (+)
AKR/J ENSMUSG00220005945
 protein coding gene Chr10:50329307-50341775 (+)
BALB/cJ ENSMUSG00180022057
 protein coding gene Chr10:50767810-50780278 (+)
C3H/HeJ ENSMUSG00175023753
 protein coding gene Chr10:50510706-50523176 (+)
C57BL/6NJ ENSMUSG00215015572
 protein coding gene Chr10:50272898-50285366 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015321
 protein coding gene Chr10:48396635-48409100 (+)
CAST/EiJ ENSTCUG00005008485
 protein coding gene Chr10:50492865-50505584 (+)
CBA/J ENSMUSG00210030146
 protein coding gene Chr10:50416515-50428983 (+)
DBA/2J ENSMUSG00185037822
 protein coding gene Chr10:50568258-50580726 (+)
FVB/NJ ENSMUSG00205004376
 protein coding gene Chr10:50502409-50514877 (+)
JF1/MsJ ENSUMUG00000023828
 protein coding gene Chr10:50258561-50271186 (+)
LP/J ENSMUSG00230022493
 protein coding gene Chr10:52369657-52382125 (+)
NOD/ShiLtJ ENSMUSG00190005344
 protein coding gene Chr10:50734997-50747465 (+)
NZO/HlLtJ ENSMUSG00225021755
 protein coding gene Chr10:56650570-56663038 (+)
PWK/PhJ ENSLUMG00010004498
 protein coding gene Chr10:50418041-50430756 (+)
SPRET/EiJ ENSMSPG00010023570
 protein coding gene Chr10:51790897-51803647 (+)
WSB/EiJ ENSIUOG00005036100
 protein coding gene Chr10:50371794-50384263 (+)



Homology
more
  • Human Ortholog
    ASF1A, anti-silencing function 1A histone chaperone
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASF1A, anti-silencing function 1A histone chaperone
  • Synonyms
    CGI-98, CIA, HSPC146
  • Links
    NCBI Gene ID: 25842
    UniProt: Q9Y294

  • Chr Location
    6q22.31; chr6:118894152-118909171 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die at midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    64
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66403 NCBI Gene Model | MGI Sequence Detail 12265 C57BL/6J ±  kb
    transcript NM_025541 RefSeq | MGI Sequence Detail 2192 C57BL/6  
    polypeptide Q9CQE6 UniProt | EBI | MGI Sequence Detail 204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143923
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory