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Alkbh7 Gene Detail
Summary
  • Symbol
    Alkbh7
  • Name
    alkB homolog 7
  • Synonyms
    2310045B01Rik, 2510008E23Rik, Abh7, Spata11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913650
    NCBI Gene: 66400
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57304339-57306322 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.61 cM, cytoband E1.1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913650
 protein coding gene Chr17:57304339-57306340 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023946
 protein coding gene Chr17:58741718-58743703 (+)
A/J MGP_AJ_G0023904
 protein coding gene Chr17:57118661-57120645 (+)
AKR/J MGP_AKRJ_G0023873
 protein coding gene Chr17:57841540-57843523 (+)
BALB/cJ MGP_BALBcJ_G0023905
 protein coding gene Chr17:56959117-56961100 (+)
C3H/HeJ MGP_C3HHeJ_G0023669
 protein coding gene Chr17:58563788-58565771 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024351
 protein coding gene Chr17:61005374-61007357 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021797
 protein coding gene Chr17:53598462-53600441 (+)
CAST/EiJ MGP_CASTEiJ_G0023151
 protein coding gene Chr17:58852995-58854977 (+)
CBA/J MGP_CBAJ_G0023645
 protein coding gene Chr17:63405160-63407142 (+)
DBA/2J MGP_DBA2J_G0023773
 protein coding gene Chr17:55816262-55818245 (+)
FVB/NJ MGP_FVBNJ_G0023739
 protein coding gene Chr17:55386573-55388558 (+)
LP/J MGP_LPJ_G0023855
 protein coding gene Chr17:59419335-59421320 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023767
 protein coding gene Chr17:62850264-62852249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024395
 protein coding gene Chr17:58202644-58204627 (+)
PWK/PhJ MGP_PWKPhJ_G0022897
 protein coding gene Chr17:55184117-55186094 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022708
 protein coding gene Chr17:54971835-54973810 (+)
WSB/EiJ MGP_WSBEiJ_G0023217
 protein coding gene Chr17:58819059-58821042 (+)



Homology
more
  • Human Ortholog
    ALKBH7, alkB homolog 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH7, alkB homolog 7
  • Synonyms
    ABH7, SPATA11, UNQ6002
  • Links
    NCBI Gene ID: 84266
    neXtProt AC: NX_Q9BT30
    UniProt: Q9BT30

  • Chr Location
    19p13.3; chr19:6372794-6375250 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects lipid and carbohydrate metabolism which leads to obesity and increased sensitivity to diet-induced obesity. It also increases resistance to alkylation-induced cell death and mortality in males (and females for some tissues) and protects the heart from ischemia-reperfusion (IR) injury in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    39
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002661 Ensembl Gene Model | MGI Sequence Detail 1984 C57BL/6J ±  kb
    transcript ENSMUST00000002737 Ensembl | MGI Sequence Detail 917 Not Applicable  
    polypeptide ENSMUSP00000002737 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000003954 alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
      (term hierarchy)
    • EC
      1.14.11.-
    • InterPro Domains
      IPR032870 Alpha-ketoglutarate-dependent dioxygenase alkB homologue 7-like
      IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like
      IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917538
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:298649 Kulkarni CA, et al., ALKBH7 mediates necrosis via rewiring of glyoxal metabolism. Elife. 2020 Aug 14;9:e58573
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory