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Ccdc28b Gene Detail
Summary
  • Symbol
    Ccdc28b
  • Name
    coiled coil domain containing 28B
  • Synonyms
    1110002E08Rik, 1810010N17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913514
    NCBI Gene: 66264
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129513067-129517740 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.26 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913514
 protein coding gene Chr4:129513067-129517820 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028834
 protein coding gene Chr4:131557040-131561513 (-)
A/J MGP_AJ_G0028793
 protein coding gene Chr4:126296493-126300986 (-)
AKR/J MGP_AKRJ_G0028746
 protein coding gene Chr4:129819705-129824186 (-)
BALB/cJ MGP_BALBcJ_G0028816
 protein coding gene Chr4:126904087-126908582 (-)
C3H/HeJ MGP_C3HHeJ_G0028530
 protein coding gene Chr4:129872920-129877397 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029258
 protein coding gene Chr4:136501926-136506671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026530
 protein coding gene Chr4:119426791-119431258 (-)
CAST/EiJ MGP_CASTEiJ_G0027962
 protein coding gene Chr4:128062472-128066945 (-)
CBA/J MGP_CBAJ_G0028496
 protein coding gene Chr4:139896811-139901302 (-)
DBA/2J MGP_DBA2J_G0028645
 protein coding gene Chr4:126732751-126737230 (-)
FVB/NJ MGP_FVBNJ_G0028612
 protein coding gene Chr4:125489216-125493685 (-)
LP/J MGP_LPJ_G0028746
 protein coding gene Chr4:131837814-131842287 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028638
 protein coding gene Chr4:144703065-144707534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029296
 protein coding gene Chr4:130189066-130193559 (-)
PWK/PhJ MGP_PWKPhJ_G0027684
 protein coding gene Chr4:123333036-123337769 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027510
 protein coding gene Chr4:126056977-126061490 (-)
WSB/EiJ MGP_WSBEiJ_G0028043
 protein coding gene Chr4:130316200-130320673 (-)



Homology
more
  • Human Ortholog
    CCDC28B, coiled-coil domain containing 28B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC28B, coiled-coil domain containing 28B
  • Links
    NCBI Gene ID: 79140
    neXtProt AC: NX_Q9BUN5
    UniProt: Q9BUN5

  • Chr Location
    1p35.2; chr1:32196011-32205453 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CCDC28B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice with no protein expression show a mild cilia length decrease in the brain, social interaction defects, increase in stereotypical behaviors, and mild glucose management phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    12
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028795 Ensembl Gene Model | MGI Sequence Detail 4674 C57BL/6J ±  kb
    transcript ENSMUST00000106035 Ensembl | MGI Sequence Detail 821 Not Applicable  
    polypeptide ENSMUSP00000101652 Ensembl | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921087
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:325766 Fabregat M, et al., Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with mild social behavioral phenotypes. PLoS Genet. 2022 Jun;18(6):e1009896
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory