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Foxo4 Gene Detail
Summary
  • Symbol
    Foxo4
  • Name
    forkhead box O4
  • Synonyms
    afx, Afxh, Foxo4, Mllt7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891915
    NCBI Gene: 54601
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100298134-100304479 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891915
 protein coding gene ChrX:100297855-100304479 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035953
 protein coding gene ChrX:97753017-97760174 (+)
A/J MGP_AJ_G0035938
 protein coding gene ChrX:97759693-97766038 (+)
AKR/J MGP_AKRJ_G0035854
 protein coding gene ChrX:100557812-100564159 (+)
BALB/cJ MGP_BALBcJ_G0035921
 protein coding gene ChrX:96498351-96504679 (+)
C3H/HeJ MGP_C3HHeJ_G0035630
 protein coding gene ChrX:98160346-98166911 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036450
 protein coding gene ChrX:100661116-100667433 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033280
 protein coding gene ChrX:95514019-95520376 (+)
CAST/EiJ MGP_CASTEiJ_G0034917
 protein coding gene ChrX:82464644-82470972 (+)
CBA/J MGP_CBAJ_G0035605
 protein coding gene ChrX:103774759-103782790 (+)
DBA/2J MGP_DBA2J_G0035759
 protein coding gene ChrX:96973561-96979885 (+)
FVB/NJ MGP_FVBNJ_G0035697
 protein coding gene ChrX:96356857-96363530 (+)
LP/J MGP_LPJ_G0035849
 protein coding gene ChrX:98715130-98721475 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035732
 protein coding gene ChrX:108326565-108332931 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036477
 protein coding gene ChrX:97446424-97452768 (+)
PWK/PhJ MGP_PWKPhJ_G0034616
 protein coding gene ChrX:80071830-80078200 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034444
 protein coding gene ChrX:83370517-83376839 (+)
WSB/EiJ MGP_WSBEiJ_G0035056
 protein coding gene ChrX:96150781-96158249 (+)



Homology
more
  • Human Ortholog
    FOXO4, forkhead box O4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXO4, forkhead box O4
  • Synonyms
    AFX, AFX1, MLLT7
  • Links
    NCBI Gene ID: 4303
    neXtProt AC: NX_P98177
    UniProt: P98177

  • Chr Location
    Xq13.1; chrX:71095851-71103532 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hemizygous and homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable histological abnormalities in most tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    96
  • cDNA Data
    38
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042903 Ensembl Gene Model | MGI Sequence Detail 6346 C57BL/6J ±  kb
    transcript ENSMUST00000062000 Ensembl | MGI Sequence Detail 3162 Not Applicable  
    polypeptide ENSMUSP00000059420 Ensembl | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 38
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 10
      Phenotypes 74
    • Earliest
      J:63676 Furuyama T, et al., Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J. 2000 Jul 15;349(Pt 2):629-34
    • Latest
      J:345016 Penniman CM, et al., Loss of FoxOs in muscle increases strength and mitochondrial function during aging. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):243-259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory