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Gde1 Gene Detail
Summary
  • Symbol
    Gde1
  • Name
    glycerophosphodiester phosphodiesterase 1
  • Synonyms
    1200003M13Rik, MIR16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891827
    NCBI Gene: 56209
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118287781-118304961 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.52 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891827
 protein coding gene Chr7:118287768-118305001 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032902
 protein coding gene Chr7:122548379-122566791 (-)
A/J MGP_AJ_G0032885
 protein coding gene Chr7:119433112-119450378 (-)
AKR/J MGP_AKRJ_G0032817
 protein coding gene Chr7:122485891-122504213 (-)
BALB/cJ MGP_BALBcJ_G0032890
 protein coding gene Chr7:119148961-119166630 (-)
C3H/HeJ MGP_C3HHeJ_G0032600
 protein coding gene Chr7:122379807-122398453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033396
 protein coding gene Chr7:127444174-127461469 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030368
 protein coding gene Chr7:120868038-120886099 (-)
CAST/EiJ MGP_CASTEiJ_G0031928
 protein coding gene Chr7:114140056-114163927 (-)
CBA/J MGP_CBAJ_G0032573
 protein coding gene Chr7:131698729-131716802 (-)
DBA/2J MGP_DBA2J_G0032725
 protein coding gene Chr7:117468330-117485852 (-)
FVB/NJ MGP_FVBNJ_G0032678
 protein coding gene Chr7:117311192-117328706 (-)
LP/J MGP_LPJ_G0032819
 protein coding gene Chr7:124012162-124030356 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032710
 protein coding gene Chr7:133180027-133202709 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033416
 protein coding gene Chr7:121490536-121509787 (-)
PWK/PhJ MGP_PWKPhJ_G0031636
 protein coding gene Chr7:110370806-110388994 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031483
 protein coding gene Chr7:108205139-108227849 (-)
WSB/EiJ MGP_WSBEiJ_G0032041
 protein coding gene Chr7:122374166-122393166 (-)



Homology
more
  • Human Ortholog
    GDE1, glycerophosphodiester phosphodiesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDE1, glycerophosphodiester phosphodiesterase 1
  • Synonyms
    363E6.2, MIR16
  • Links
    NCBI Gene ID: 51573
    neXtProt AC: NX_Q9NZC3
    UniProt: Q9NZC3

  • Chr Location
    16p12.3; chr16:19501693-19522123 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack glycero-phospho-N-acyl ethanolamine (GP-NAE) phosphodiesterase activity in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    21
  • cDNA Data
    115
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56209 NCBI Gene Model | MGI Sequence Detail 17181 C57BL/6J ±  kb
    transcript NM_019580 RefSeq | MGI Sequence Detail 1529 C57BL/6  
    polypeptide Q9JL56 UniProt | EBI | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 115

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913360
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:64687 Zheng B, et al., MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3999-4004
    • Latest
      J:234535 Tsuboi K, et al., Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis. Biochim Biophys Acta. 2015 May;1851(5):537-48
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory