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Stub1 Gene Detail
Summary
  • Symbol
    Stub1
  • Name
    STIP1 homology and U-Box containing protein 1
  • Synonyms
    0610033N24Rik, 2210017D18Rik, 2310040B03Rik, CHIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891731
    NCBI Gene: 56424
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26049608-26051893 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.93 cM, cytoband B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891731
 protein coding gene Chr17:26049479-26052378 (-)
129S1/SvImJ ENSMUSG00200049461
 protein coding gene Chr17:21494472-21497371 (-)
A/J ENSMUSG00195048152
 protein coding gene Chr17:22511666-22514565 (-)
AKR/J ENSMUSG00220053215
 protein coding gene Chr17:21558421-21561320 (-)
BALB/cJ ENSMUSG00180047163
 protein coding gene Chr17:21792478-21795377 (-)
C3H/HeJ ENSMUSG00175053656
 protein coding gene Chr17:21550723-21553622 (-)
C57BL/6NJ ENSMUSG00215053018
 protein coding gene Chr17:21559064-21561963 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021255
 protein coding gene Chr17:21665082-21667809 (-)
CAST/EiJ ENSTCUG00005046938
 protein coding gene Chr17:22140565-22143464 (-)
CBA/J ENSMUSG00210049254
 protein coding gene Chr17:21389564-21392463 (-)
DBA/2J ENSMUSG00185040580
 protein coding gene Chr17:23599931-23602830 (-)
FVB/NJ ENSMUSG00205035985
 protein coding gene Chr17:21855385-21858284 (-)
JF1/MsJ ENSUMUG00000055575
 protein coding gene Chr17:23055239-23058136 (-)
LP/J ENSMUSG00230054497
 protein coding gene Chr17:24999007-25001906 (-)
NOD/ShiLtJ ENSMUSG00190054078
 protein coding gene Chr17:21488646-21491545 (-)
NZO/HlLtJ ENSMUSG00225052777
 protein coding gene Chr17:26918997-26921896 (-)
PWK/PhJ ENSLUMG00010038724
 protein coding gene Chr17:20974368-20977267 (-)
SPRET/EiJ ENSMSPG00010047243
 protein coding gene Chr17:22293261-22296153 (-)
WSB/EiJ ENSIUOG00005046386
 protein coding gene Chr17:22232311-22235210 (-)



Homology
more
  • Human Ortholog
    STUB1, STIP1 homology and U-box containing protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STUB1, STIP1 homology and U-box containing protein 1
  • Synonyms
    CHIP, HSPABP2, NY-CO-7, SCA48, SCAR16, SDCCAG7, UBOX1
  • Links
    NCBI Gene ID: 10273
    UniProt: Q9UNE7

  • Chr Location
    16p13.3; chr16:679980-682870 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Stub1 mouse models; 2 with human STUB1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 5 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop normally but are susceptible to stress-induced apoptosis of multiple organs. Increased peri- and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    199
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    11
  • cDNA Data
    12
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56424 NCBI Gene Model | MGI Sequence Detail 2286 C57BL/6J ±  kb
    transcript NR_157362 RefSeq | MGI Sequence Detail 1410 ZRU/MplStud  
    polypeptide Q9WUD1 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913330, MGI:1916886, MGI:1917365, MGI:2147033
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 23
      Phenotypes 41
    • Earliest
      J:59260 Fukunishi Y, et al., Prediction of human cDNA from its homologous mouse full-length cDNA and human shotgun database. FEBS Lett. 1999 Dec 31;464(3):129-32
    • Latest
      J:387870 Cong P, et al., Curcumin alleviates cold stress-induced myocardial injury by regulating macrophage polarization through the STUB1/STAT1-STAT6-KLF4 signaling axis. Int Immunopharmacol. 2026 Jun 19;185:117045
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory