Atp5mk MGI Mouse Gene Detail - MGI:1891435 - ATP synthase membrane subunit k

Symbol

Atp5mk
Name

ATP synthase membrane subunit k
Synonyms

2010301L15Rik, Atp5md, Usmg5

Feature Type

protein coding gene
IDs

MGI:1891435
NCBI Gene: 66477
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:47071910-47079086 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 39.23 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

345 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891435	protein coding gene	Chr19:47071903-47079086 (-)
129S1/SvImJ	ENSMUSG00200020339	protein coding gene	Chr19:43778239-43785418 (-)
A/J	ENSMUSG00195016582	protein coding gene	Chr19:43908855-43916036 (-)
AKR/J	ENSMUSG00220018570	protein coding gene	Chr19:43714005-43721186 (-)
BALB/cJ	ENSMUSG00180017069	protein coding gene	Chr19:44160896-44168077 (-)
C3H/HeJ	ENSMUSG00175005978	protein coding gene	Chr19:43706944-43714125 (-)
C57BL/6NJ	ENSMUSG00215004658	protein coding gene	Chr19:43770650-43777829 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	ENSTCUG00005015298	protein coding gene	Chr19:43368305-43375090 (-)
CBA/J	ENSMUSG00210018026	protein coding gene	Chr19:43786438-43793619 (-)
DBA/2J	ENSMUSG00185008373	protein coding gene	Chr19:44284265-44291446 (-)
FVB/NJ	ENSMUSG00205029325	protein coding gene	Chr19:43202242-43209423 (-)
JF1/MsJ	ENSUMUG00000028415	protein coding gene	Chr19:44443785-44451013 (-)
LP/J	ENSMUSG00230023760	protein coding gene	Chr19:45047822-45055001 (-)
NOD/ShiLtJ	ENSMUSG00190004921	protein coding gene	Chr19:43650756-43657937 (-)
NZO/HlLtJ	ENSMUSG00225043892	protein coding gene	Chr19:48643626-48650807 (-)
PWK/PhJ	ENSLUMG00010001099	protein coding gene	Chr19:43609626-43616845 (-)
SPRET/EiJ	ENSMSPG00010007299	protein coding gene	Chr19:43344913-43349709 (-)
WSB/EiJ	ENSIUOG00005005880	protein coding gene	Chr19:43155575-43162758 (-)

Human Ortholog

ATP5MK, ATP synthase membrane subunit k

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP5MK, ATP synthase membrane subunit k
Synonyms

AGP, ATP5MD, bA792D24.4, DAPIT, HCVFTP2, MC5DN6, USMG5
Links

HGNC:30889

NCBI Gene ID: 84833

UniProt: Q96IX5
Chr Location

10q24.33; chr10:103388991-103396492 (-) GRCh38

MGI Vertebrate Homology

Atp5mk stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATP5MK
Gene Tree

Atp5mk

Diseases

1 with human ATP5MK associations

				Human Disease	Mouse Models
				mitochondrial complex V (ATP synthase) deficiency nuclear type 6 IDs mitochondrial complex V (ATP synthase) deficiency nuclear type 6 DOID:0111749 OMIM:618683

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

1
Gene trapped

26
Targeted

3
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

9

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

658
Tissues

45
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp5mk

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS38014.1

Ensembl

ENSMUSG00000071528 (Evidence)
NCBI Gene

66477

			Length	Strain/Species	Flank
genomic	66477	NCBI Gene Model \| MGI Sequence Detail	7177	C57BL/6J	± kb
transcript	NM_023211	RefSeq \| MGI Sequence Detail	363	C57BL/6
polypeptide	Q78IK2	UniProt \| EBI \| MGI Sequence Detail	58	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017143 ATP synthase F(0) complex subunit k, mitochondrial

(term hierarchy)
InterPro Domains

IPR009125 ATP synthase membrane subunit K
GlyGen

Q78IK2 1 site, 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 4

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MGI:1913727, MGI:6277083, MGI:7469651

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atp5mk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159698	Chr19:47079304-47079317 (-)	-225 bp
Tssr159697	Chr19:47079140-47079143 (-)	-56 bp
Tssr159696	Chr19:47079117-47079122 (-)	-34 bp
Tssr159695	Chr19:47079049-47079094 (-)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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