About   Help   FAQ
Mov10l1 Gene Detail
Summary
  • Symbol
    Mov10l1
  • Name
    Mov10 like RISC complex RNA helicase 1
  • Synonyms
    CHAMP, Csm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891384
    NCBI Gene: 83456
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:88867112-88939355 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1378 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891384
 protein coding gene Chr15:88867094-88939355 (+)
129S1/SvImJ ENSMUSG00200033906
 protein coding gene Chr15:86018872-86093747 (+)
A/J ENSMUSG00195016607
 protein coding gene Chr15:85940496-86015555 (+)
AKR/J ENSMUSG00220026788
 protein coding gene Chr15:85971083-86046153 (+)
BALB/cJ ENSMUSG00180014271
 protein coding gene Chr15:85794338-85869397 (+)
C3H/HeJ ENSMUSG00175024646
 protein coding gene Chr15:86127166-86202224 (+)
C57BL/6NJ ENSMUSG00215024155
 protein coding gene Chr15:85887865-85962932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020148
 protein coding gene Chr15:82937835-83000609 (+)
CAST/EiJ ENSTCUG00005028312
 protein coding gene Chr15:85394920-85469865 (+)
CBA/J ENSMUSG00210012955
 protein coding gene Chr15:85896627-85971690 (+)
DBA/2J ENSMUSG00185022079
 protein coding gene Chr15:85908508-85983571 (+)
FVB/NJ ENSMUSG00205025167
 protein coding gene Chr15:85669461-85744427 (+)
JF1/MsJ ENSUMUG00000030891
 protein coding gene Chr15:85479808-85551010 (+)
LP/J ENSMUSG00230041436
 protein coding gene Chr15:89259062-89333940 (+)
NOD/ShiLtJ ENSMUSG00190022970
 protein coding gene Chr15:85916525-85987697 (+)
NZO/HlLtJ ENSMUSG00225048931
 protein coding gene Chr15:89575625-89650682 (+)
PWK/PhJ ENSLUMG00010032200
 protein coding gene Chr15:85633034-85704174 (+)
SPRET/EiJ ENSMSPG00010012157
 protein coding gene Chr15:87333703-87399741 (+)
WSB/EiJ ENSIUOG00005010482
 protein coding gene Chr15:86003492-86078428 (+)



Homology
more
  • Human Ortholog
    MOV10L1, Mov10 like RNA helicase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOV10L1, Mov10 like RNA helicase 1
  • Synonyms
    CHAMP, DJ402G11.8, SPGF73
  • Links
    NCBI Gene ID: 54456
    UniProt: Q9BXT6

  • Chr Location
    22q13.33; chr22:50090006-50161690 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MOV10L1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele lacking the helicase domain exhibit male infertility due to meiotic arrest, apoptosis, and derepression of retrotransposons in male germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    680
  • Tissues
    33
  • cDNA Data
    20
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015365 Ensembl Gene Model | MGI Sequence Detail 72244 C57BL/6J ±  kb
    transcript ENSMUST00000146993 Ensembl | MGI Sequence Detail 4133 Not Applicable  
    polypeptide ENSMUSP00000118437 Ensembl | MGI Sequence Detail 1239 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 20
      Primer pair 5
      Other 3
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 11
      Phenotypes 46
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory