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Dkk2 Gene Detail
Summary
  • Symbol
    Dkk2
  • Name
    dickkopf WNT signaling pathway inhibitor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890663
    NCBI Gene: 56811
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:131791053-131886065 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.32 cM, cytoband H2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2868 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890663
 protein coding gene Chr3:131791027-131886065 (+)
129S1/SvImJ ENSMUSG00200003489
 protein coding gene Chr3:128566212-128661232 (+)
A/J ENSMUSG00195007786
 protein coding gene Chr3:128671819-128766858 (+)
AKR/J ENSMUSG00220021919
 protein coding gene Chr3:127111153-127206157 (+)
BALB/cJ ENSMUSG00180003277
 protein coding gene Chr3:128600758-128695778 (+)
C3H/HeJ ENSMUSG00175013560
 protein coding gene Chr3:128174525-128269543 (+)
C57BL/6NJ ENSMUSG00215017523
 protein coding gene Chr3:128946069-129041107 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025642
 protein coding gene Chr3:125548951-125642883 (+)
CAST/EiJ ENSTCUG00005003597
 protein coding gene Chr3:129242928-129338836 (+)
CBA/J ENSMUSG00210003609
 protein coding gene Chr3:128792319-128887335 (+)
DBA/2J ENSMUSG00185025385
 protein coding gene Chr3:129395888-129491004 (+)
FVB/NJ ENSMUSG00205017413
 protein coding gene Chr3:127726768-127821802 (+)
JF1/MsJ ENSUMUG00000016243
 protein coding gene Chr3:128128698-128226100 (+)
LP/J ENSMUSG00230004228
 protein coding gene Chr3:131384794-131479813 (+)
NOD/ShiLtJ ENSMUSG00190001207
 protein coding gene Chr3:129788953-129883951 (+)
NZO/HlLtJ ENSMUSG00225005470
 protein coding gene Chr3:133825695-133920812 (+)
PWK/PhJ ENSLUMG00010014888
 protein coding gene Chr3:128132448-128228959 (+)
SPRET/EiJ ENSMSPG00010011861
 protein coding gene Chr3:129123831-129218344 (+)
WSB/EiJ ENSIUOG00005016436
 protein coding gene Chr3:128936136-129031166 (+)



Homology
more
  • Human Ortholog
    DKK2, dickkopf Wnt signaling pathway inhibitor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DKK2, dickkopf Wnt signaling pathway inhibitor 2
  • Synonyms
    DKK-2
  • Links
    NCBI Gene ID: 27123
    UniProt: Q9UBU2

  • Chr Location
    4q25; chr4:106921802-107283806 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
mice homozygous for a targeted disruption are osteopenic with defective mineralization of induced osteoblasts in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1009
  • Tissues
    316
  • cDNA Data
    25
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028031 Ensembl Gene Model | MGI Sequence Detail 95013 C57BL/6J ±  kb
    transcript ENSMUST00000029665 Ensembl | MGI Sequence Detail 3705 Not Applicable  
    polypeptide ENSMUSP00000029665 Ensembl | MGI Sequence Detail 259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006500 dickkopf-related protein 2
      (term hierarchy)
    • PDB
      2JTK
    • InterPro Domains
      IPR006796 Dickkopf, N-terminal cysteine-rich
      IPR048500 Dickkopf-related protein 1/2/4, C-terminal subdomain 1
      IPR048499 Dickkopf-related protein 1/2/4, C-terminal subdomain 2
      IPR039863 Dickkopf related protein 1-4
      IPR047303 Dickkopf-related protein 2, first cysteine-rich domain
      IPR047302 Dickkopf-related protein 2, second cysteine-rich domain
    • GlyGen
      Q9QYZ8 1 site
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 27
      Primer pair 19
      Other 7
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 67
      Diseases 1
      Gene Ontology 7
      Phenotypes 31
    • Earliest
      J:57798 Monaghan AP, et al., Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
    • Latest
      J:390509 Huang BL, et al., A pivotal Wnt antagonist role promoting digit joint specification by constraining Wnt activity. Nat Commun. 2026 May 26;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory