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Nherf2 Gene Detail
Summary
  • Symbol
    Nherf2
  • Name
    NHERF family PDZ scaffold protein 2
  • Synonyms
    0610011L07Rik, 1200011K07Rik, 2010007A20Rik, E3karp, Nherf2, Octs2, Sip-1, Sip1, Slc9a3r2, Sryip1, Tka-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890662
    NCBI Gene: 65962
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24858255-24869279 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.43 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890662
 protein coding gene Chr17:24858255-24869301 (-)
129S1/SvImJ ENSMUSG00200045602
 protein coding gene Chr17:20304283-20315203 (-)
A/J ENSMUSG00195052178
 protein coding gene Chr17:21323124-21334044 (-)
AKR/J ENSMUSG00220025934
 protein coding gene Chr17:20369418-20380371 (-)
BALB/cJ ENSMUSG00180041026
 protein coding gene Chr17:20602953-20613896 (-)
C3H/HeJ ENSMUSG00175048894
 protein coding gene Chr17:20361368-20372277 (-)
C57BL/6NJ ENSMUSG00215051456
 protein coding gene Chr17:20366370-20377412 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021194
 protein coding gene Chr17:20469971-20480838 (-)
CAST/EiJ ENSTCUG00005048797
 protein coding gene Chr17:20936470-20947372 (-)
CBA/J ENSMUSG00210049953
 protein coding gene Chr17:20200199-20211108 (-)
DBA/2J ENSMUSG00185042631
 protein coding gene Chr17:22411467-22422387 (-)
FVB/NJ ENSMUSG00205041173
 protein coding gene Chr17:20663155-20674061 (-)
JF1/MsJ ENSUMUG00000057245
 protein coding gene Chr17:21858149-21869209 (-)
LP/J ENSMUSG00230054950
 protein coding gene Chr17:23808843-23819992 (-)
NOD/ShiLtJ ENSMUSG00190048101
 protein coding gene Chr17:20300205-20311124 (-)
NZO/HlLtJ ENSMUSG00225052839
 protein coding gene Chr17:25730510-25741655 (-)
PWK/PhJ ENSLUMG00010017830
 protein coding gene Chr17:19767712-19778689 (-)
SPRET/EiJ ENSMSPG00010046960
 protein coding gene Chr17:21101116-21112157 (-)
WSB/EiJ ENSIUOG00005049747
 protein coding gene Chr17:21048787-21059741 (-)



Homology
more
  • Human Ortholog
    NHERF2, NHERF family PDZ scaffold protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NHERF2, NHERF family PDZ scaffold protein 2
  • Synonyms
    E3KARP, NHE3RF2, NHERF-2, OCTS2, SIP-1, SIP1, SLC9A3R2, TKA-1
  • Links
    NCBI Gene ID: 9351
    UniProt: Q15599

  • Chr Location
    16p13.3; chr16:2025356-2039026 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile and overtly normal and display normal cAMP- and cGMP-activated CFTR transepithelial chloride transport and bicarbonate secretion in the small intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    7
  • cDNA Data
    69
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65962 NCBI Gene Model | MGI Sequence Detail 11025 C57BL/6J ±  kb
    transcript NM_023055 RefSeq | MGI Sequence Detail 2118 C57BL/6  
    polypeptide Q9JHL1 UniProt | EBI | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 69
      Primer pair 1
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1915060, MGI:1915601, MGI:1923770, MGI:2178113, MGI:7388570
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:75423 Zhang J, et al., In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Biol. 1999 May;43(3):219-27
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory