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Cntrl Gene Detail
Summary
  • Symbol
    Cntrl
  • Name
    centriolin
  • Synonyms
    6720467O09Rik, b2b1468Clo, Cep1, Cep110, IB3/5, Ma2a8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889576
    NCBI Gene: 26920
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:34999504-35068834 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 23.36 cM, cytoband B-C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1626 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889576
 protein coding gene Chr2:34999504-35068834 (+)
129S1/SvImJ ENSMUSG00200046331
 protein coding gene Chr2:31981253-32047807 (+)
A/J ENSMUSG00195038468
 protein coding gene Chr2:32083252-32149818 (+)
AKR/J ENSMUSG00220043111
 protein coding gene Chr2:32198190-32264752 (+)
BALB/cJ ENSMUSG00180048498
 protein coding gene Chr2:32097645-32164201 (+)
C3H/HeJ ENSMUSG00175038724
 protein coding gene Chr2:32063975-32130542 (+)
C57BL/6NJ ENSMUSG00215045633
 protein coding gene Chr2:32131111-32197669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023476
 protein coding gene Chr2:30988193-31056740 (+)
CAST/EiJ ENSTCUG00005017061
 protein coding gene Chr2:31792965-31861028 (+)
CBA/J ENSMUSG00210048404
 protein coding gene Chr2:32136306-32202865 (+)
DBA/2J ENSMUSG00185045393
 protein coding gene Chr2:31996138-32062699 (+)
FVB/NJ ENSMUSG00205021030
 protein coding gene Chr2:31843986-31910551 (+)
JF1/MsJ ENSUMUG00000008858
 protein coding gene Chr2:31877441-31945465 (+)
LP/J ENSMUSG00230045350
 protein coding gene Chr2:33916601-33983157 (+)
NOD/ShiLtJ ENSMUSG00190031797
 protein coding gene Chr2:32097494-32164053 (+)
NZO/HlLtJ ENSMUSG00225049132
 protein coding gene Chr2:41671705-41739640 (+)
PWK/PhJ ENSLUMG00010040994
 protein coding gene Chr2:31979087-32046950 (+)
SPRET/EiJ ENSMSPG00010035280
 protein coding gene Chr2:32669954-32739728 (+)
WSB/EiJ ENSIUOG00005036790
 protein coding gene Chr2:31967355-32035629 (+)



Homology
more
  • Human Ortholog
    CNTRL, centriolin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNTRL, centriolin
  • Synonyms
    bA165P4.1, CEP1, CEP110, FAN
  • Links
    NCBI Gene ID: 11064
    UniProt: Q7Z7A1

  • Chr Location
    9q33.2; chr9:121074660-121177729 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cntrl mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    13 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit cardiac defects, including double outlet right ventricle, atrial septal defects, ventricular septal defects, tricuspid valve stenosis and heart right ventricle hypoplasia, and develop kidney cysts and hydronephrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    3
  • cDNA Data
    90
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26920 NCBI Gene Model | MGI Sequence Detail 69331 C57BL/6J ±  kb
    transcript NM_012018 RefSeq | MGI Sequence Detail 7612 Not Specified  
    polypeptide A2AL36 UniProt | EBI | MGI Sequence Detail 2334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      Genomic 1
      cDNA 92

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1349397, MGI:1925147, MGI:2138818, MGI:5438043
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:51736 Angiolillo A, et al., Molecular cloning of a cDNA encoding an antigen which is salt-stably attached to centrosomes. Biochim Biophys Acta. 1996 Dec 11;1309(3):194-6
    • Latest
      J:376526 Sakai T, et al., Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis. Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2503931122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory