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Poll Gene Detail
Summary
  • Symbol
    Poll
  • Name
    polymerase (DNA directed), lambda
  • Synonyms
    1110003P06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889000
    NCBI Gene: 56626
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45540714-45548970 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889000
 protein coding gene Chr19:45540714-45549025 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025188
 protein coding gene Chr19:45158510-45166703 (-)
A/J MGP_AJ_G0025165
 protein coding gene Chr19:42953625-42961828 (-)
AKR/J MGP_AKRJ_G0025133
 protein coding gene Chr19:44334508-44342667 (-)
BALB/cJ MGP_BALBcJ_G0025159
 protein coding gene Chr19:43006703-43014578 (-)
C3H/HeJ MGP_C3HHeJ_G0024919
 protein coding gene Chr19:44513816-44521784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025602
 protein coding gene Chr19:46288246-46296398 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023016
 protein coding gene Chr19:42206821-42214967 (-)
CAST/EiJ MGP_CASTEiJ_G0024384
 protein coding gene Chr19:44258068-44266084 (-)
CBA/J MGP_CBAJ_G0024899
 protein coding gene Chr19:48604714-48613999 (-)
DBA/2J MGP_DBA2J_G0025031
 protein coding gene Chr19:42766015-42774218 (-)
FVB/NJ MGP_FVBNJ_G0024992
 protein coding gene Chr19:42549585-42558564 (-)
LP/J MGP_LPJ_G0025117
 protein coding gene Chr19:45078376-45086225 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025023
 protein coding gene Chr19:47949294-47957176 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025660
 protein coding gene Chr19:44411340-44419549 (-)
PWK/PhJ MGP_PWKPhJ_G0024133
 protein coding gene Chr19:42688662-42698740 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023937
 protein coding gene Chr19:43098331-43112058 (-)
WSB/EiJ MGP_WSBEiJ_G0024454
 protein coding gene Chr19:44568623-44578251 (-)



Homology
more
  • Human Ortholog
    POLL, DNA polymerase lambda
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLL, DNA polymerase lambda
  • Synonyms
    BETAN, POLKAPPA
  • Links
    NCBI Gene ID: 27343
    neXtProt AC: NX_Q9UGP5
    UniProt: Q9UGP5

  • Chr Location
    10q24.32; chr10:101578882-101588270 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit defective heavy chain rearrangement. See also the Dpcd gene for mutations that affect both of these overlapping genes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    27
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025218 Ensembl Gene Model | MGI Sequence Detail 8257 C57BL/6J ±  kb
transcript ENSMUST00000026239 Ensembl | MGI Sequence Detail 2324 Not Applicable  
polypeptide ENSMUSP00000026239 Ensembl | MGI Sequence Detail 573 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 2
    cDNA 27
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1923540, MGI:2147667
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:64121 Garcia-Diaz M, et al., DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis. J Mol Biol. 2000 Aug 25;301(4):851-67
  • Latest
    J:334109 Cova G, et al., Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3. Nat Commun. 2023 Mar 17;14(1):1475
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory