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Ntn4 Gene Detail
Summary
  • Symbol
    Ntn4
  • Name
    netrin 4
  • Synonyms
    beta-netrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888978
    NCBI Gene: 57764
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:93476911-93581834 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 48.59 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3299 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888978
 protein coding gene Chr10:93476543-93583069 (+)
129S1/SvImJ ENSMUSG00200028180
 protein coding gene Chr10:89982480-90086033 (+)
A/J ENSMUSG00195019971
 protein coding gene Chr10:90420328-90523942 (+)
AKR/J ENSMUSG00220020056
 protein coding gene Chr10:89987906-90091694 (+)
BALB/cJ ENSMUSG00180031934
 protein coding gene Chr10:90423064-90526613 (+)
C3H/HeJ ENSMUSG00175021288
 protein coding gene Chr10:90323853-90427452 (+)
C57BL/6NJ ENSMUSG00215018444
 protein coding gene Chr10:90006845-90113444 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015736
 protein coding gene Chr10:87352013-87461819 (+)
CAST/EiJ ENSTCUG00005033083
 protein coding gene Chr10:89709970-89816018 (+)
CBA/J ENSMUSG00210034341
 protein coding gene Chr10:90158969-90262570 (+)
DBA/2J ENSMUSG00185037640
 protein coding gene Chr10:90370903-90474539 (+)
FVB/NJ ENSMUSG00205015612
 protein coding gene Chr10:90073620-90177211 (+)
JF1/MsJ ENSUMUG00000025693
 protein coding gene Chr10:91786653-91893073 (+)
LP/J ENSMUSG00230021235
 protein coding gene Chr10:92278772-92382289 (+)
NOD/ShiLtJ ENSMUSG00190017818
 protein coding gene Chr10:90408272-90511848 (+)
NZO/HlLtJ ENSMUSG00225020924
 protein coding gene Chr10:96528766-96632446 (+)
PWK/PhJ ENSLUMG00010021182
 protein coding gene Chr10:90053401-90160365 (+)
SPRET/EiJ ENSMSPG00010009909
 protein coding gene Chr10:91669053-91776275 (+)
WSB/EiJ ENSIUOG00005034356
 protein coding gene Chr10:90103747-90207406 (+)



Homology
more
  • Human Ortholog
    NTN4, netrin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTN4, netrin 4
  • Synonyms
    PRO3091
  • Links
    NCBI Gene ID: 59277
    UniProt: Q9HB63

  • Chr Location
    12q22; chr12:95657807-95791189 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased cell proliferation in the cornea without an increase in corneal thickness and increased microvessel branching in the middle levels of the retina.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    109
  • cDNA Data
    10
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57764 NCBI Gene Model | MGI Sequence Detail 104924 C57BL/6J ±  kb
    transcript NM_021320 RefSeq | MGI Sequence Detail 2411 C57BL/6  
    polypeptide Q9JI33 UniProt | EBI | MGI Sequence Detail 628 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 10
      Primer pair 3
      Other 3
      Antibodies 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 20
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:388212 Zhu Z, et al., A neurovascular survival axis for adult sympathetic neurons. Neuron. 2026 May 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory