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Ppbp Gene Detail
Summary
  • Symbol
    Ppbp
  • Name
    pro-platelet basic protein
  • Synonyms
    2400003M24Rik, beta-TG, b-TG1, CTAP3, CTAPIII, Cxcl7, LA-PF4, LDGF, MDGF, NAP-2, NAP-2, NAP-2-L1, Scyb7, TGB, TGB1, THBGB1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888712
    NCBI Gene: 57349
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90916377-90917922 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888712
 protein coding gene Chr5:90916377-90917922 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029727
 protein coding gene Chr5:91859426-91860971 (+)
A/J MGP_AJ_G0029693
 protein coding gene Chr5:88233175-88234720 (+)
AKR/J MGP_AKRJ_G0029639
 protein coding gene Chr5:91095469-91097014 (+)
BALB/cJ MGP_BALBcJ_G0029703
 protein coding gene Chr5:89134150-89135693 (+)
C3H/HeJ MGP_C3HHeJ_G0029426
 protein coding gene Chr5:91514111-91515654 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030157
 protein coding gene Chr5:95531422-95532967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027393
 protein coding gene Chr5:83937701-83939244 (+)
CAST/EiJ MGP_CASTEiJ_G0028836
 protein coding gene Chr5:90886834-90888377 (+)
CBA/J MGP_CBAJ_G0029396
 protein coding gene Chr5:98803503-98805046 (+)
DBA/2J MGP_DBA2J_G0029540
 protein coding gene Chr5:88307923-88309466 (+)
FVB/NJ MGP_FVBNJ_G0029499
 protein coding gene Chr5:87167901-87169444 (+)
LP/J MGP_LPJ_G0029628
 protein coding gene Chr5:92238056-92239601 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029528
 protein coding gene Chr5:103786846-103788389 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030191
 protein coding gene Chr5:90636702-90638247 (+)
PWK/PhJ MGP_PWKPhJ_G0028555
 protein coding gene Chr5:87366693-87368238 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028390
 protein coding gene Chr5:90054703-90056249 (+)
WSB/EiJ MGP_WSBEiJ_G0028915
 protein coding gene Chr5:91095461-91097006 (+)



Homology
more
  • Human Ortholog
    PPBP, pro-platelet basic protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPBP, pro-platelet basic protein
  • Synonyms
    Beta-TG, B-TG1, CTAP3, CTAPIII, CTAP-III, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
  • Links
    NCBI Gene ID: 5473
    neXtProt AC: NX_P02775
    UniProt: P02775

  • Chr Location
    4q13.3; chr4:73986439-73988190 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPBP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired leukocyte shape change and migration following vascular injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    30
  • cDNA Data
    21
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57349 NCBI Gene Model | MGI Sequence Detail 1546 C57BL/6J ±  kb
    transcript NM_023785 RefSeq | MGI Sequence Detail 1098 C57BL/6  
    polypeptide NP_076274 RefSeq | MGI Sequence Detail 113 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922842, MGI:2141003
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:293091 Li Z, et al., Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24122-24132
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory