Apba3 MGI Mouse Gene Detail - MGI:1888527 - amyloid beta precursor protein binding family A member 3

Symbol

Apba3
Name

amyloid beta precursor protein binding family A member 3
Synonyms

lin-10, Mint 3, Mint-3, neuronal munc18-1-interacting protein 3, neuron-specific X11L2 protein, X11gamma

Feature Type

protein coding gene
IDs

MGI:1888527
NCBI Gene: 57267
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:81102799-81109081 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

167 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1888527	protein coding gene	Chr10:81102794-81109081 (+)
129S1/SvImJ	ENSMUSG00200044198	protein coding gene	Chr10:77731756-77736223 (+)
A/J	ENSMUSG00195049138	protein coding gene	Chr10:78127026-78131493 (+)
AKR/J	ENSMUSG00220046836	protein coding gene	Chr10:77724715-77729182 (+)
BALB/cJ	ENSMUSG00180052219	protein coding gene	Chr10:78137479-78141946 (+)
C3H/HeJ	ENSMUSG00175049748	protein coding gene	Chr10:78008232-78012697 (+)
C57BL/6NJ	ENSMUSG00215052312	protein coding gene	Chr10:77750091-77754558 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015630	protein coding gene	Chr10:75268714-75273933 (+)
CAST/EiJ	ENSTCUG00005051391	protein coding gene	Chr10:77631769-77636236 (+)
CBA/J	ENSMUSG00210049084	protein coding gene	Chr10:77864258-77868725 (+)
DBA/2J	ENSMUSG00185046494	protein coding gene	Chr10:78206691-78211158 (+)
FVB/NJ	ENSMUSG00205029418	protein coding gene	Chr10:77919506-77923973 (+)
JF1/MsJ	ENSUMUG00000020627	protein coding gene	Chr10:79434071-79438534 (+)
LP/J	ENSMUSG00230050669	protein coding gene	Chr10:79976275-79980742 (+)
NOD/ShiLtJ	ENSMUSG00190043305	protein coding gene	Chr10:78120390-78124857 (+)
NZO/HlLtJ	ENSMUSG00225052568	protein coding gene	Chr10:84262844-84267311 (+)
PWK/PhJ	ENSLUMG00010044688	protein coding gene	Chr10:77797756-77802221 (+)
SPRET/EiJ	ENSMSPG00010031571	protein coding gene	Chr10:79407350-79412402 (+)
WSB/EiJ	ENSIUOG00005050117	protein coding gene	Chr10:77860448-77864916 (+)

Human Ortholog

APBA3, amyloid beta precursor protein binding family A member 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APBA3, amyloid beta precursor protein binding family A member 3
Synonyms

MGC:15815, mint3, X11L2
Links

HGNC:580

NCBI Gene ID: 9546

UniProt: O96018
Chr Location

19p13.3; chr19:3750772-3761700 (-) GRCh38

MGI Vertebrate Homology

Apba3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: APBA3
Gene Tree

Apba3

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

5
Genomic Mutations

1 involving Apba3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Deletion in mutants causes abnormalities in colon morphology and physiology, increased circulating blood urea nitrogen, and decreased serum chloride, sodium and potassium levels. Surviving homozygotes display diarrhea, postnatal viability and decreased life span.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

49

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase apba3

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All Sequences

69
RefSeq

15
UniProt

6
CCDS

CCDS24050.1

Ensembl

ENSMUSG00000004931 (Evidence)
NCBI Gene

57267

			Length	Strain/Species	Flank
genomic	57267	NCBI Gene Model \| MGI Sequence Detail	6283	C57BL/6J	± kb
transcript	NR_190703	RefSeq \| MGI Sequence Detail	2063	C57BL/6
polypeptide	O88888	UniProt \| EBI \| MGI Sequence Detail	571	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004117 amyloid-beta A4 precursor protein-binding family A member 3

(term hierarchy)
InterPro Domains

IPR051230 Amyloid-beta A4 Precursor Protein-Binding

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR006020 PTB/PI domain
GlyGen

O88888 1 site, 1 N-linked glycan (1 site)

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All nucleic 51

cDNA 51

Microarray probesets 3

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MGI:2143823

Summaries

All 52

Gene Ontology 6

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:361919 Nishitani M, et al., Mint3 as a Molecular Target Activated in the Early Stage of Hepatocarcinogenesis. Int J Mol Sci. 2025 Feb 8;26(4)

TSS for Apba3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94727	Chr10:81102527-81102550 (+)	-260 bp
Tssr94728	Chr10:81104010-81104039 (+)	1,226 bp
Tssr94729	Chr10:81104041-81104104 (+)	1,274 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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