Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Ccr5tm1Kuz Name: C-C motif chemokine receptor 5; targeted mutation 1, William A Kuziel MGI ID: MGI:1861911 Synonyms: CCR5-, CCR5 KO, Cmkbr5tm1Kuz Gene: Ccr5  Location: Chr9:123921557-123934153 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F Alliance: Ccr5tm1Kuz page

Ccr5tm1Kuz/Ccr5tm1Kuz and wild-type littermates underwent bile duct ligation or sham operation. Macrophage infiltration was determined by immunohistochemistry for F4/80 Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:64293
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon containing the entire coding region was replaced with a neomycin resistance gene inserted by homologous recombination. (J:84243)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ccr5 Mutation:	29 strains or lines available

Original:	J:64293 Huffnagle GB, et al., Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol. 1999 Nov 1;163(9):4642-6
All:	188 reference(s)