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Nme6 Gene Detail
Summary
  • Symbol
    Nme6
  • Name
    NME/NM23 nucleoside diphosphate kinase 6
  • Synonyms
    nm23-M6, non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861676
    NCBI Gene: 54369
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:109661830-109672042 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    552 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861676
 protein coding gene Chr9:109661817-109672184 (+)
129S1/SvImJ ENSMUSG00200038839
 protein coding gene Chr9:106755243-106765138 (+)
A/J ENSMUSG00195043887
 protein coding gene Chr9:106047524-106057759 (+)
AKR/J ENSMUSG00220026360
 protein coding gene Chr9:106383255-106393485 (+)
BALB/cJ ENSMUSG00180027392
 protein coding gene Chr9:106502446-106512685 (+)
C3H/HeJ ENSMUSG00175033044
 protein coding gene Chr9:106718337-106728576 (+)
C57BL/6NJ ENSMUSG00215014957
 protein coding gene Chr9:106598502-106608734 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032721
 protein coding gene Chr9:105117811-105127943 (+)
CAST/EiJ ENSTCUG00005028276
 protein coding gene Chr9:106418067-106428087 (+)
CBA/J ENSMUSG00210030779
 protein coding gene Chr9:106431380-106441287 (+)
DBA/2J ENSMUSG00185041244
 protein coding gene Chr9:106766348-106776572 (+)
FVB/NJ ENSMUSG00205048993
 protein coding gene Chr9:106696796-106706692 (+)
JF1/MsJ ENSUMUG00000028923
 protein coding gene Chr9:106533707-106543614 (+)
LP/J ENSMUSG00230043555
 protein coding gene Chr9:106887458-106897353 (+)
NOD/ShiLtJ ENSMUSG00190041265
 protein coding gene Chr9:106353966-106364210 (+)
NZO/HlLtJ ENSMUSG00225024200
 protein coding gene Chr9:107136913-107146813 (+)
PWK/PhJ ENSLUMG00010036125
 protein coding gene Chr9:106549302-106559251 (+)
SPRET/EiJ ENSMSPG00010042925
 protein coding gene Chr9:108340919-108352495 (+)
WSB/EiJ ENSIUOG00005045583
 protein coding gene Chr9:105812513-105822416 (+)



Homology
more
  • Human Ortholog
    NME6, NME/NM23 nucleoside diphosphate kinase 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NME6, NME/NM23 nucleoside diphosphate kinase 6
  • Synonyms
    IPIA-ALPHA, NDK 6, NDK6, NM23-H6
  • Links
    NCBI Gene ID: 10201
    UniProt: O75414

  • Chr Location
    3p21.31; chr3:48287640-48301685 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    131
  • cDNA Data
    60
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54369 NCBI Gene Model | MGI Sequence Detail 10213 C57BL/6J ±  kb
transcript NM_001409696 RefSeq | MGI Sequence Detail 1198 C57BL/6  
polypeptide O88425 UniProt | EBI | MGI Sequence Detail 189 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 61
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:62651 Mehus JG, et al., NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Hum Genet. 1999 Jun;104(6):454-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory