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Cpsf2 Gene Detail
Summary
  • Symbol
    Cpsf2
  • Name
    cleavage and polyadenylation specific factor 2
  • Synonyms
    100kDa, 2610024B04Rik, Cpsf, mKIAA1367
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861601
    NCBI Gene: 51786
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:101942247-101972683 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 51.34 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861601
 protein coding gene Chr12:101940345-101972683 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020028
 protein coding gene Chr12:103582536-103616647 (+)
A/J MGP_AJ_G0019984
 protein coding gene Chr12:99606269-99636189 (+)
AKR/J MGP_AKRJ_G0019960
 protein coding gene Chr12:102446343-102479201 (+)
BALB/cJ MGP_BALBcJ_G0019970
 protein coding gene Chr12:99948690-99980529 (+)
C3H/HeJ MGP_C3HHeJ_G0019772
 protein coding gene Chr12:102894256-102926787 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020419
 protein coding gene Chr12:106827324-106857954 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018032
 protein coding gene Chr12:96632195-96662517 (+)
CAST/EiJ MGP_CASTEiJ_G0019318
 protein coding gene Chr12:97716463-97776929 (+)
CBA/J MGP_CBAJ_G0019744
 protein coding gene Chr12:110766832-110798523 (+)
DBA/2J MGP_DBA2J_G0019855
 protein coding gene Chr12:99132226-99162266 (+)
FVB/NJ MGP_FVBNJ_G0019844
 protein coding gene Chr12:97851258-97881993 (+)
LP/J MGP_LPJ_G0019931
 protein coding gene Chr12:103438329-103471250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019884
 protein coding gene Chr12:114263839-114296094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020448
 protein coding gene Chr12:101944509-101974893 (+)
PWK/PhJ MGP_PWKPhJ_G0019081
 protein coding gene Chr12:93684732-93716816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018877
 protein coding gene Chr12:96121938-96154674 (+)
WSB/EiJ MGP_WSBEiJ_G0019372
 protein coding gene Chr12:102827411-102858245 (+)



Homology
more
  • Human Ortholog
    CPSF2, cleavage and polyadenylation specific factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPSF2, cleavage and polyadenylation specific factor 2
  • Synonyms
    CPSF100
  • Links
    NCBI Gene ID: 53981
    neXtProt AC: NX_Q9P2I0
    UniProt: Q9P2I0

  • Chr Location
    14q32.12; chr14:92121969-92172145 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    15
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041781 Ensembl Gene Model | MGI Sequence Detail 30437 C57BL/6J ±  kb
transcript ENSMUST00000047357 Ensembl | MGI Sequence Detail 5732 Not Applicable  
polypeptide ENSMUSP00000047797 Ensembl | MGI Sequence Detail 782 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005829 cleavage and polyadenylation specificity factor subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR022712 Beta-Casp domain
    IPR025069 Cleavage and polyadenylation specificity factor 2, C-terminal
    IPR027075 Cleavage and polyadenylation specificity factor subunit 2
    IPR035639 CPSF2, metallo-hydrolase domain
    IPR001279 Metallo-beta-lactamase
    IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
    IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
less
MGI:1917185, MGI:2144878
References
more
  • Summaries
    All 43
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326556 Wang Y, et al., DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Nat Commun. 2022 Jul 1;13(1):3794
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory