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Apbb1ip Gene Detail
Summary
  • Symbol
    Apbb1ip
  • Name
    amyloid beta precursor protein binding family B member 1 interacting protein
  • Synonyms
    9930118P07Rik, proline-rich protein 48, Prp48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861354
    NCBI Gene: 54519
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:22664106-22765665 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 15.15 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    459 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861354
 protein coding gene Chr2:22645983-22765671 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025392
 protein coding gene Chr2:20505829-20611852 (+)
A/J MGP_AJ_G0025370
 protein coding gene Chr2:19668159-19766363 (+)
AKR/J MGP_AKRJ_G0025339
 protein coding gene Chr2:20380722-20483553 (+)
BALB/cJ MGP_BALBcJ_G0025365
 protein coding gene Chr2:19782394-19880688 (+)
C3H/HeJ MGP_C3HHeJ_G0025126
 protein coding gene Chr2:20282845-20387792 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025809
 protein coding gene Chr2:21103522-21208603 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023223
 protein coding gene Chr2:18767940-18866637 (+)
CAST/EiJ MGP_CASTEiJ_G0024589
 protein coding gene Chr2:20194237-20305668 (+)
CBA/J MGP_CBAJ_G0025104
 protein coding gene Chr2:21903237-22012401 (+)
DBA/2J MGP_DBA2J_G0025237
 protein coding gene Chr2:19569865-19671739 (+)
FVB/NJ MGP_FVBNJ_G0025199
 protein coding gene Chr2:19357168-19457168 (+)
LP/J MGP_LPJ_G0025323
 protein coding gene Chr2:20443367-20547809 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025230
 protein coding gene Chr2:21945146-22059958 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025868
 protein coding gene Chr2:20256371-20359325 (+)
PWK/PhJ MGP_PWKPhJ_G0024338
 protein coding gene Chr2:19385548-19485143 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024138
 protein coding gene Chr2:20378362-20488344 (+)
WSB/EiJ MGP_WSBEiJ_G0024659
 protein coding gene Chr2:20389670-20510096 (+)



Homology
more
  • Human Ortholog
    APBB1IP, amyloid beta precursor protein binding family B member 1 interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APBB1IP, amyloid beta precursor protein binding family B member 1 interacting protein
  • Synonyms
    INAG1, PREL1, RARP1, RIAM
  • Links
    NCBI Gene ID: 54518
    neXtProt AC: NX_Q7Z5R6
    UniProt: Q7Z5R6

  • Chr Location
    10p12.1; chr10:26438341-26567803 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and healthy with no apparent defects in platelet integrin activation and function, hemostasis, or arterial thrombus formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    13
  • cDNA Data
    24
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026786 Ensembl Gene Model | MGI Sequence Detail 101560 C57BL/6J ±  kb
    transcript ENSMUST00000014290 Ensembl | MGI Sequence Detail 2773 Not Applicable  
    polypeptide ENSMUSP00000014290 Ensembl | MGI Sequence Detail 670 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442489
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:44866 Ermekova KS, et al., The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J Biol Chem. 1997 Dec 26;272(52):32869-77
    • Latest
      J:341186 Sun H, et al., IL-2 can signal via chemokine receptors to promote regulatory T cells' suppressive function. Cell Rep. 2023 Aug 29;42(8):112996
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory