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Actr8 Gene Detail
Summary
  • Symbol
    Actr8
  • Name
    ARP8 actin-related protein 8
  • Synonyms
    5730542K05Rik, ARP8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860775
    NCBI Gene: 56249
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:29700294-29717409 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 18.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860775
 protein coding gene Chr14:29700294-29728311 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021099
 protein coding gene Chr14:23083001-23097885 (+)
A/J MGP_AJ_G0021047
 protein coding gene Chr14:22211613-22226497 (+)
AKR/J MGP_AKRJ_G0021024
 protein coding gene Chr14:23297499-23320038 (+)
BALB/cJ MGP_BALBcJ_G0021051
 protein coding gene Chr14:22303938-22319050 (+)
C3H/HeJ MGP_C3HHeJ_G0020834
 protein coding gene Chr14:23161531-23180243 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021483
 protein coding gene Chr14:24001477-24016361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019046
 protein coding gene Chr14:22283348-22297792 (+)
CAST/EiJ MGP_CASTEiJ_G0020359
 protein coding gene Chr14:22883345-22899477 (+)
CBA/J MGP_CBAJ_G0020801
 protein coding gene Chr14:24924562-24942061 (+)
DBA/2J MGP_DBA2J_G0020923
 protein coding gene Chr14:22255398-22270282 (+)
FVB/NJ MGP_FVBNJ_G0020907
 protein coding gene Chr14:22203482-22218542 (+)
LP/J MGP_LPJ_G0020992
 protein coding gene Chr14:23402580-23417464 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020933
 protein coding gene Chr14:24236686-24252844 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021516
 protein coding gene Chr14:23061304-23076188 (+)
PWK/PhJ MGP_PWKPhJ_G0020107
 protein coding gene Chr14:21679493-21695207 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019931
 protein coding gene Chr14:22623638-22638888 (+)
WSB/EiJ MGP_WSBEiJ_G0020414
 protein coding gene Chr14:23118899-23133848 (+)



Homology
more
  • Human Ortholog
    ACTR8, actin related protein 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTR8, actin related protein 8
  • Synonyms
    ARP8, hArp8, INO80N
  • Links
    NCBI Gene ID: 93973
    neXtProt AC: NX_Q9H981
    UniProt: Q9H981

  • Chr Location
    3p21.1; chr3:53858992-53882152 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    18
  • cDNA Data
    59
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56249 NCBI Gene Model | MGI Sequence Detail 17116 C57BL/6J ±  kb
    transcript NM_027493 RefSeq | MGI Sequence Detail 2121 Not Specified  
    polypeptide Q8R2S9 UniProt | EBI | MGI Sequence Detail 624 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 60
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917897
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:62084 Tian E, et al., Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Oncogene. 2000 Apr 20;19(17):2098-109
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory