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Gucy1b1 Gene Detail
Summary
  • Symbol
    Gucy1b1
  • Name
    guanylate cyclase 1, soluble, beta 1
  • Synonyms
    beta 1 sGC, Gucy1b3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860604
    NCBI Gene: 54195
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:81939313-81981996 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1196 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860604
 protein coding gene Chr3:81939311-81982018 (-)
129S1/SvImJ ENSMUSG00200018783
 protein coding gene Chr3:78791823-78834489 (-)
A/J ENSMUSG00195011774
 protein coding gene Chr3:78799787-78842410 (-)
AKR/J ENSMUSG00220001254
 protein coding gene Chr3:78755869-78798559 (-)
BALB/cJ ENSMUSG00180001876
 protein coding gene Chr3:78928740-78971435 (-)
C3H/HeJ ENSMUSG00175007022
 protein coding gene Chr3:78726454-78769071 (-)
C57BL/6NJ ENSMUSG00215001961
 protein coding gene Chr3:79179280-79221966 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025097
 protein coding gene Chr3:74888407-74930125 (-)
CAST/EiJ ENSTCUG00005001532
 protein coding gene Chr3:78266792-78309679 (-)
CBA/J ENSMUSG00210025234
 protein coding gene Chr3:78856988-78899602 (-)
DBA/2J ENSMUSG00185012615
 protein coding gene Chr3:79013424-79056121 (-)
FVB/NJ ENSMUSG00205006132
 protein coding gene Chr3:77784234-77826926 (-)
JF1/MsJ ENSUMUG00000001111
 protein coding gene Chr3:78535699-78578590 (-)
LP/J ENSMUSG00230008060
 protein coding gene Chr3:81000423-81043091 (-)
NOD/ShiLtJ ENSMUSG00190002696
 protein coding gene Chr3:79252486-79295166 (-)
NZO/HlLtJ ENSMUSG00225005405
 protein coding gene Chr3:83731946-83774625 (-)
PWK/PhJ ENSLUMG00010006180
 protein coding gene Chr3:78605054-78647856 (-)
SPRET/EiJ ENSMSPG00010016221
 protein coding gene Chr3:79407677-79450884 (-)
WSB/EiJ ENSIUOG00005003027
 protein coding gene Chr3:79230542-79273207 (-)



Homology
more
  • Human Ortholog
    GUCY1B1, guanylate cyclase 1 soluble subunit beta 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCY1B1, guanylate cyclase 1 soluble subunit beta 1
  • Synonyms
    GC-SB3, GC-S-beta-1, GUC1B3, GUCB3, GUCSB3, GUCY1B3
  • Links
    NCBI Gene ID: 2983
    UniProt: Q02153

  • Chr Location
    4q32.1; chr4:155758988-155807811 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 5 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice that bypass neonatal lethality die prematurely due to severe gastrointestinal obstruction and exhibit hypertension, reduced heart rate, lack of glycerol trinitrate-induced drop in systolic pressure, and lack of a nitric oxide effect on aortic relaxation and platelet aggregation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    142
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028005 Ensembl Gene Model | MGI Sequence Detail 42684 C57BL/6J ±  kb
    transcript ENSMUST00000029635 Ensembl | MGI Sequence Detail 3223 Not Applicable  
    polypeptide ENSMUSP00000029635 Ensembl | MGI Sequence Detail 620 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:5927632
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:64709 Sharina IG, et al., Genomic organization of alpha 1 and beta 1 subunits of the mammalian soluble guanylyl cyclase genes. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10878-83
    • Latest
      J:352463 He H, et al., Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury. J Exp Med. 2023 Feb 6;220(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory