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Heyl Gene Detail
Summary
  • Symbol
    Heyl
  • Name
    hairy/enhancer-of-split related with YRPW motif-like
  • Synonyms
    bHLHb33, Hesr3, Hey3, Hrt3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860511
    NCBI Gene: 56198
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123127349-123143663 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    469 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860511
 protein coding gene Chr4:123127349-123143668 (+)
129S1/SvImJ ENSMUSG00200013947
 protein coding gene Chr4:116563133-116579450 (+)
A/J ENSMUSG00195028298
 protein coding gene Chr4:117893735-117910051 (+)
AKR/J ENSMUSG00220021982
 protein coding gene Chr4:116861780-116878101 (+)
BALB/cJ ENSMUSG00180041294
 protein coding gene Chr4:115531896-115548219 (+)
C3H/HeJ ENSMUSG00175024817
 protein coding gene Chr4:116544939-116561261 (+)
C57BL/6NJ ENSMUSG00215021092
 protein coding gene Chr4:118038825-118055144 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026434
 protein coding gene Chr4:113017960-113034701 (+)
CAST/EiJ ENSTCUG00005042598
 protein coding gene Chr4:117402309-117418564 (+)
CBA/J ENSMUSG00210052501
 protein coding gene Chr4:116151264-116167586 (+)
DBA/2J ENSMUSG00185046210
 protein coding gene Chr4:117706480-117722800 (+)
FVB/NJ ENSMUSG00205011191
 protein coding gene Chr4:115914957-115931283 (+)
JF1/MsJ ENSUMUG00000006380
 protein coding gene Chr4:118340591-118356843 (+)
LP/J ENSMUSG00230044207
 protein coding gene Chr4:121501234-121517551 (+)
NOD/ShiLtJ ENSMUSG00190027769
 protein coding gene Chr4:115908592-115924916 (+)
NZO/HlLtJ ENSMUSG00225015599
 protein coding gene Chr4:127408765-127425084 (+)
PWK/PhJ ENSLUMG00010037805
 protein coding gene Chr4:115362127-115378437 (+)
SPRET/EiJ ENSMSPG00010030797
 protein coding gene Chr4:117489614-117503660 (+)
WSB/EiJ ENSIUOG00005044543
 protein coding gene Chr4:115776515-115792850 (+)



Homology
more
  • Human Ortholog
    HEYL, hes related family bHLH transcription factor with YRPW motif like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HEYL, hes related family bHLH transcription factor with YRPW motif like
  • Synonyms
    bHLHb33, HESR3, HEY3, HRT3
  • Links
    NCBI Gene ID: 26508
    UniProt: Q9NQ87

  • Chr Location
    1p34.2; chr1:39623435-39639643 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced TrkC+ sensory neurons in the dorsal root ganglia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1035
  • Tissues
    268
  • cDNA Data
    43
  • Literature Summary
    94
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56198 NCBI Gene Model | MGI Sequence Detail 16315 C57BL/6J ±  kb
transcript NM_013905 RefSeq | MGI Sequence Detail 4532 C57BL/6  
polypeptide Q9DBX7 UniProt | EBI | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008530 hairy/enhancer-of-split related with YRPW motif-like protein
    (term hierarchy)
  • InterPro Domains
    IPR050370 Hairy and Enhancer of Split/HEY-related
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
less
  • All nucleic 59
    Genomic 2
    cDNA 44
    Primer pair 6
    Other 7

    Microarray probesets 5
Other
Accession IDs
less
MGI:1353482
References
more
  • Summaries
    All 159
    Developmental Gene Expression 94
    Gene Ontology 17
    Phenotypes 30
  • Earliest
    J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
  • Latest
    J:359963 de Haan S, et al., Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea. Development. 2024 Nov 1;151(21)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory