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Msgn1 Gene Detail
Summary
  • Symbol
    Msgn1
  • Name
    mesogenin 1
  • Synonyms
    Msgn
Location &
Maps
more
  • Sequence Map
    Chr12:11258383-11258949 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 5.58 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860483
 protein coding gene Chr12:11258361-11258973 (-)
129S1/SvImJ ENSMUSG00200023466
 protein coding gene Chr12:8252070-8252682 (-)
A/J ENSMUSG00195015313
 protein coding gene Chr12:8275341-8275953 (-)
AKR/J ENSMUSG00220028081
 protein coding gene Chr12:8311095-8311707 (-)
BALB/cJ ENSMUSG00180014759
 protein coding gene Chr12:8267831-8268443 (-)
C3H/HeJ ENSMUSG00175008923
 protein coding gene Chr12:8281487-8282099 (-)
C57BL/6NJ ENSMUSG00215012240
 protein coding gene Chr12:8101869-8102481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017615
 protein coding gene Chr12:7850471-7851037 (-)
CAST/EiJ ENSTCUG00005022293
 protein coding gene Chr12:7892816-7893428 (-)
CBA/J ENSMUSG00210013427
 protein coding gene Chr12:8303510-8304122 (-)
DBA/2J ENSMUSG00185020369
 protein coding gene Chr12:8269815-8270427 (-)
FVB/NJ ENSMUSG00205003087
 protein coding gene Chr12:8005828-8006440 (-)
JF1/MsJ ENSUMUG00000027571
 protein coding gene Chr12:8179924-8180536 (-)
LP/J ENSMUSG00230018349
 protein coding gene Chr12:10065180-10065792 (-)
NOD/ShiLtJ ENSMUSG00190007812
 protein coding gene Chr12:9523975-9524587 (-)
NZO/HlLtJ ENSMUSG00225029579
 protein coding gene Chr12:12165331-12165943 (-)
PWK/PhJ ENSLUMG00010016055
 protein coding gene Chr12:7955976-7956588 (-)
SPRET/EiJ ENSMSPG00010004800
 protein coding gene Chr12:8680916-8681528 (-)
WSB/EiJ ENSIUOG00005002290
 protein coding gene Chr12:8297689-8298301 (-)



Homology
more
  • Human Ortholog
    MSGN1, mesogenin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSGN1, mesogenin 1
  • Synonyms
    MSOG, pMsgn1
  • Links
    NCBI Gene ID: 343930
    UniProt: A6NI15

  • Chr Location
    2p24.2; chr2:17816460-17817798 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die during gestation, displaying severe disruption of somitogenesis and enlargement of the tailbud. Later in development, homozygotes show a striking absence of all trunk and tail skeletal muscle and axial skeleton, whereas the hindlimb skeleton remains unaffected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    186
  • cDNA Data
    9
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56184 NCBI Gene Model | MGI Sequence Detail 567 C57BL/6J ±  kb
    transcript NM_019544 RefSeq | MGI Sequence Detail 567 Not Specified  
    polypeptide Q9JK54 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 9
      Primer pair 3
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 36
      Gene Ontology 8
      Phenotypes 4
    • Earliest
      J:62914 Yoon JK, et al., The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol. 2000 Jun 15;222(2):376-91
    • Latest
      J:367359 Menezes NA, et al., Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations. Nat Commun. 2025 May 29;16(1):5000
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory