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Phc2 Gene Detail
Summary
  • Symbol
    Phc2
  • Name
    polyhomeotic 2
  • Synonyms
    D130050K19Rik, D4Ertd810e, Edr2, Mph2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860454
    NCBI Gene: 54383
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:128548495-128646674 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 62.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1188 from dbSNP Build 142
  • Strain Annotations
    27
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860454
 protein coding gene Chr4:128548448-128646674 (+)
129S1/SvImJ ENSMUSG00200018300
 protein coding gene Chr4:122073044-122082571 (+)
129S1/SvImJ ENSMUSGG00200054887
 protein coding gene Chr4:122034453-122041667 (+)
A/J ENSMUSG00195035873
 protein coding gene Chr4:123413085-123422602 (+)
A/J ENSMUSGG00195055420
 protein coding gene Chr4:123374697-123381893 (+)
AKR/J ENSMUSG00220036169
 protein coding gene Chr4:122403557-122413084 (+)
AKR/J ENSMUSGG00220054394
 protein coding gene Chr4:122365200-122372396 (+)
BALB/cJ ENSMUSGG00180055194
 protein coding gene Chr4:121008350-121015546 (+)
BALB/cJ ENSMUSG00180037993
 protein coding gene Chr4:121046744-121056261 (+)
C3H/HeJ ENSMUSGG00175054717
 protein coding gene Chr4:122021003-122028199 (+)
C3H/HeJ ENSMUSG00175022685
 protein coding gene Chr4:122059389-122068906 (+)
C57BL/6NJ ENSMUSGG00215055281
 protein coding gene Chr4:123521567-123528763 (+)
C57BL/6NJ ENSMUSG00215051249
 protein coding gene Chr4:123559921-123569448 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026502
 protein coding gene Chr4:118452237-118549570 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210052071
 protein coding gene Chr4:121688256-121697773 (+)
CBA/J ENSMUSGG00210054569
 protein coding gene Chr4:121649866-121657062 (+)
DBA/2J ENSMUSG00185047202
 protein coding gene Chr4:123220828-123230345 (+)
DBA/2J ENSMUSGG00185057927
 protein coding gene Chr4:123182436-123189632 (+)
FVB/NJ ENSMUSG00205016666
 protein coding gene Chr4:121446274-121455797 (+)
FVB/NJ ENSMUSGG00205054228
 protein coding gene Chr4:121407659-121414873 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230031905
 protein coding gene Chr4:127010574-127020101 (+)
LP/J ENSMUSGG00230055385
 protein coding gene Chr4:126971983-126979197 (+)
NOD/ShiLtJ ENSMUSGG00190054562
 protein coding gene Chr4:121408067-121415281 (+)
NOD/ShiLtJ ENSMUSG00190047281
 protein coding gene Chr4:121446626-121456149 (+)
NZO/HlLtJ ENSMUSG00225015460
 protein coding gene Chr4:132931105-132940632 (+)
NZO/HlLtJ ENSMUSGG00225055204
 protein coding gene Chr4:132892757-132899953 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010036709
 protein coding gene Chr4:122925269-122989621 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PHC2, polyhomeotic homolog 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHC2, polyhomeotic homolog 2
  • Synonyms
    EDR2, HPH2, PH2
  • Links
    NCBI Gene ID: 1912
    UniProt: Q8IXK0

  • Chr Location
    1p35.1; chr1:33323623-33431095 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 5 alleles in 2 genetic backgrounds
    29 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    52
  • cDNA Data
    10
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028796 Ensembl Gene Model | MGI Sequence Detail 98180 C57BL/6J ±  kb
    transcript ENSMUST00000106080 Ensembl | MGI Sequence Detail 3885 Not Applicable  
    polypeptide ENSMUSP00000101690 Ensembl | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289316, MGI:2140153, MGI:2441942
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 11
      Gene Ontology 18
      Phenotypes 19
    • Earliest
      J:62648 Hemenway CS, et al., The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains. Oncogene. 1998 May 14;16(19):2541-7
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory