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Rcor2 Gene Detail
Summary
  • Symbol
    Rcor2
  • Name
    REST corepressor 2
  • Synonyms
    1A13, CoREST
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859854
    NCBI Gene: 104383
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7244759-7252590 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859854
protein coding gene Chr19:7244690-7252590 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024788
protein coding gene Chr19:4389938-4397844 (+)
A/J MGP_AJ_G0024755
protein coding gene Chr19:4040952-4048858 (+)
AKR/J MGP_AKRJ_G0024728
protein coding gene Chr19:4171250-4179156 (+)
BALB/cJ MGP_BALBcJ_G0024755
protein coding gene Chr19:4154815-4162721 (+)
C3H/HeJ MGP_C3HHeJ_G0024522
protein coding gene Chr19:4301437-4310196 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025201
protein coding gene Chr19:4478686-4486592 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022635
protein coding gene Chr19:3946093-3954050 (+)
CAST/EiJ MGP_CASTEiJ_G0023995
protein coding gene Chr19:4205698-4213573 (+)
CBA/J MGP_CBAJ_G0024495
protein coding gene Chr19:4555361-4564034 (+)
DBA/2J MGP_DBA2J_G0024622
protein coding gene Chr19:4008583-4014534 (+)
FVB/NJ MGP_FVBNJ_G0024587
protein coding gene Chr19:4044060-4052026 (+)
LP/J MGP_LPJ_G0024708
protein coding gene Chr19:4241192-4248524 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024617
protein coding gene Chr19:4446219-4454125 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025249
protein coding gene Chr19:4315823-4323729 (+)
PWK/PhJ MGP_PWKPhJ_G0023741
protein coding gene Chr19:4056437-4064377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023545
protein coding gene Chr19:4121180-4128451 (+)
WSB/EiJ MGP_WSBEiJ_G0024057
protein coding gene Chr19:4215943-4225635 (+)



Homology
more
  • Human Ortholog
    RCOR2, REST corepressor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RCOR2, REST corepressor 2
  • Links
    NCBI Gene ID: 283248
    neXtProt AC: NX_Q8IZ40
    UniProt: Q8IZ40

  • Chr Location
    11q13.1; chr11:63911230-63927762 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for neuronal specific conditional loss of expression display impaired neurogenesis and neuronal precursor cell proliferation resulting in a thin cerebral cortex.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104383 NCBI Gene Model | MGI Sequence Detail 7832 C57BL/6J ±  kb
    transcript NM_001320554 RefSeq | MGI Sequence Detail 2840 Not Specified  
    polypeptide Q8C796 UniProt | EBI | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 38
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147708
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 20
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:61357 Grimes JA, et al., The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. J Biol Chem. 2000 Mar 31;275(13):9461-7
    • Latest
      J:327318 Pei L, et al., Rcor2 Is Required for Somatic Differentiation and Represses Germline Cell Fate. Stem Cells Int. 2022;2022:5283615

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory