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Hes6 Gene Detail
Summary
  • Symbol
    Hes6
  • Name
    hairy and enhancer of split 6
  • Synonyms
    bHLHb41
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859852
    NCBI Gene: 55927
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:91339205-91341760 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 46.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859852
 protein coding gene Chr1:91339204-91342901 (-)
129S1/SvImJ ENSMUSG00200036463
 protein coding gene Chr1:88565261-88567468 (-)
A/J ENSMUSG00195030438
 protein coding gene Chr1:88117154-88119361 (-)
AKR/J ENSMUSG00220040356
 protein coding gene Chr1:88274599-88276806 (-)
BALB/cJ ENSMUSG00180015871
 protein coding gene Chr1:88431676-88433883 (-)
C3H/HeJ ENSMUSG00175001317
 protein coding gene Chr1:88303000-88305207 (-)
C57BL/6NJ ENSMUSG00215027221
 protein coding gene Chr1:88239505-88241712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014423
 protein coding gene Chr1:83863487-83866071 (-)
CAST/EiJ ENSTCUG00005007333
 protein coding gene Chr1:87873064-87875278 (-)
CBA/J ENSMUSG00210011944
 protein coding gene Chr1:88148277-88150484 (-)
DBA/2J ENSMUSG00185013835
 protein coding gene Chr1:92618057-92620264 (-)
FVB/NJ ENSMUSG00205030503
 protein coding gene Chr1:87562647-87564854 (-)
JF1/MsJ ENSUMUG00000015245
 protein coding gene Chr1:91363024-91365231 (-)
LP/J ENSMUSG00230019849
 protein coding gene Chr1:91901416-91903623 (-)
NOD/ShiLtJ ENSMUSG00190024644
 protein coding gene Chr1:88199284-88201491 (-)
NZO/HlLtJ ENSMUSG00225002285
 protein coding gene Chr1:95802815-95805022 (-)
PWK/PhJ ENSLUMG00010041475
 protein coding gene Chr1:87755138-87757345 (-)
SPRET/EiJ ENSMSPG00010039188
 protein coding gene Chr1:89787366-89789644 (-)
WSB/EiJ ENSIUOG00005034439
 protein coding gene Chr1:87862125-87864332 (-)



Homology
more
  • Human Ortholog
    HES6, hes family bHLH transcription factor 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HES6, hes family bHLH transcription factor 6
  • Synonyms
    bHLHb41, bHLHc23, C-HAIRY1, HES-6
  • Links
    NCBI Gene ID: 55502
    UniProt: Q96HZ4

  • Chr Location
    2q37.3; chr2:238238267-238240662 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1275
  • Tissues
    383
  • cDNA Data
    84
  • Literature Summary
    57
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067071 Ensembl Gene Model | MGI Sequence Detail 2556 C57BL/6J ±  kb
transcript ENSMUST00000086851 Ensembl | MGI Sequence Detail 1335 Not Applicable  
polypeptide ENSMUSP00000084062 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 86
    Primer pair 7
    Other 5
    Antibodies 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138216
References
more
  • Summaries
    All 103
    Developmental Gene Expression 57
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:363327 Sepp M, et al., Cellular development and evolution of the mammalian cerebellum. Nature. 2024 Jan;625(7996):788-796
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory