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Mtx2 Gene Detail
Summary
  • Symbol
    Mtx2
  • Name
    metaxin 2
  • Synonyms
    1500012G02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859652
    NCBI Gene: 53375
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74656156-74707092 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.13 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    850 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859652
 protein coding gene Chr2:74656147-74708775 (+)
129S1/SvImJ ENSMUSG00200002636
 protein coding gene Chr2:71704889-71757518 (+)
A/J ENSMUSG00195019429
 protein coding gene Chr2:71851623-71904264 (+)
AKR/J ENSMUSG00220002335
 protein coding gene Chr2:71816257-71868900 (+)
BALB/cJ ENSMUSG00180006043
 protein coding gene Chr2:71805288-71857930 (+)
C3H/HeJ ENSMUSG00175010580
 protein coding gene Chr2:71931185-71983832 (+)
C57BL/6NJ ENSMUSG00215019646
 protein coding gene Chr2:71768129-71820763 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023677
 protein coding gene Chr2:69632888-69687852 (+)
CAST/EiJ ENSTCUG00005027312
 protein coding gene Chr2:71245201-71305011 (+)
CBA/J ENSMUSG00210002046
 protein coding gene Chr2:71973845-72026490 (+)
DBA/2J ENSMUSG00185010527
 protein coding gene Chr2:71809686-71862337 (+)
FVB/NJ ENSMUSG00205018170
 protein coding gene Chr2:71261654-71314295 (+)
JF1/MsJ ENSUMUG00000024802
 protein coding gene Chr2:71485957-71539199 (+)
LP/J ENSMUSG00230024357
 protein coding gene Chr2:73604485-73657123 (+)
NOD/ShiLtJ ENSMUSG00190009846
 protein coding gene Chr2:71884341-71936980 (+)
NZO/HlLtJ ENSMUSG00225014246
 protein coding gene Chr2:81368562-81421191 (+)
PWK/PhJ ENSLUMG00010028382
 protein coding gene Chr2:71724952-71777793 (+)
SPRET/EiJ ENSMSPG00010019274
 protein coding gene Chr2:73122368-73174967 (+)
WSB/EiJ ENSIUOG00005010556
 protein coding gene Chr2:71927616-71980257 (+)



Homology
more
  • Human Ortholog
    MTX2, metaxin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTX2, metaxin 2
  • Synonyms
    MDPS, metaxin-2
  • Links
    NCBI Gene ID: 10651
    UniProt: O75431

  • Chr Location
    2q31.1; chr2:176269395-176338025 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    1 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    5
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53375 NCBI Gene Model | MGI Sequence Detail 50937 C57BL/6J ±  kb
    transcript NM_016804 RefSeq | MGI Sequence Detail 1258 C57BL/6  
    polypeptide O88441 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010756 metaxin-2
      (term hierarchy)
    • InterPro Domains
      IPR036282 Glutathione S-transferase, C-terminal domain superfamily
      IPR040079 Glutathione transferase family
      IPR033468 Metaxin, glutathione S-transferase domain
      IPR019564 Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain
      IPR050931 Mitochondrial Protein Transport Metaxin
    • GlyGen
      O88441 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916200
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 33
    • Earliest
      J:10491 Davisson MT, et al., The mouse mutation ulnaless on chromosome 2. J Hered. 1990 Mar-Apr;81(2):151-3
    • Latest
      J:346399 Li T, et al., Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients. Int J Biol Sci. 2024;20(3):937-952
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory