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Pdgfc Gene Detail
Summary
  • Symbol
    Pdgfc
  • Name
    platelet-derived growth factor, C polypeptide
  • Synonyms
    1110064L01Rik, PDGF-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859631
    NCBI Gene: 54635
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:80943723-81121347 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.73 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1628 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859631
 protein coding gene Chr3:80943723-81121347 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027321
 protein coding gene Chr3:80812413-81001150 (+)
A/J MGP_AJ_G0027283
 protein coding gene Chr3:78132645-78319783 (+)
AKR/J MGP_AKRJ_G0027251
 protein coding gene Chr3:79964408-80144547 (+)
BALB/cJ MGP_BALBcJ_G0027294
 protein coding gene Chr3:78210501-78385421 (+)
C3H/HeJ MGP_C3HHeJ_G0027038
 protein coding gene Chr3:80290700-80471738 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027740
 protein coding gene Chr3:83881368-84068214 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025093
 protein coding gene Chr3:73951897-74122010 (+)
CAST/EiJ MGP_CASTEiJ_G0026485
 protein coding gene Chr3:80392681-80594374 (+)
CBA/J MGP_CBAJ_G0027013
 protein coding gene Chr3:86673056-86868155 (+)
DBA/2J MGP_DBA2J_G0027149
 protein coding gene Chr3:77690279-77866945 (+)
FVB/NJ MGP_FVBNJ_G0027117
 protein coding gene Chr3:76010364-76182651 (+)
LP/J MGP_LPJ_G0027257
 protein coding gene Chr3:81814785-81996882 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027136
 protein coding gene Chr3:92976985-93184205 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027798
 protein coding gene Chr3:79791241-79989995 (+)
PWK/PhJ MGP_PWKPhJ_G0026219
 protein coding gene Chr3:77426972-77603840 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026035
 protein coding gene Chr3:78966549-79153683 (+)
WSB/EiJ MGP_WSBEiJ_G0026563
 protein coding gene Chr3:80133020-80324537 (+)



Homology
more
  • Human Ortholog
    PDGFC, platelet derived growth factor C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDGFC, platelet derived growth factor C
  • Synonyms
    FALLOTEIN, SCDGF
  • Links
    NCBI Gene ID: 56034
    neXtProt AC: NX_Q9NRA1
    UniProt: Q9NRA1

  • Chr Location
    4q32.1; chr4:156760454-156971799 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    1 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results neonatal and postnatal lethality with cleft palate, hypoplastic palatine bones, edema, blistering, and a short nasal septum with one allele or abnormal retinal pigmentation with a second allele.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1250
  • Tissues
    207
  • cDNA Data
    17
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54635 NCBI Gene Model | MGI Sequence Detail 177625 C57BL/6J ±  kb
    transcript NM_001357746 RefSeq | MGI Sequence Detail 3596 C57BL/6  
    polypeptide Q8CI19 UniProt | EBI | MGI Sequence Detail 345 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 1
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916128, MGI:2139772
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 13
      Phenotypes 36
    • Earliest
      J:62052 Li X, et al., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
    • Latest
      J:344102 Racedo SE, et al., Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory