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Otud5 Gene Detail
Summary
  • Symbol
    Otud5
  • Name
    OTU domain containing 5
  • Synonyms
    Duba, DXImx46e, Sfc7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859615
    NCBI Gene: 54644
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7707603-7742865 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859615
 protein coding gene ChrX:7705852-7742865 (+)
129S1/SvImJ ENSMUSGG00200054464
 protein coding gene ChrX:2408142-2444508 (+)
A/J ENSMUSGG00195055116
 protein coding gene ChrX:2431111-2467476 (+)
AKR/J ENSMUSGG00220054574
 protein coding gene ChrX:2419042-2455414 (+)
BALB/cJ ENSMUSGG00180055026
 protein coding gene ChrX:2428815-2465179 (+)
C3H/HeJ ENSMUSGG00175054767
 protein coding gene ChrX:2442783-2479145 (+)
C57BL/6NJ ENSMUSGG00215055192
 protein coding gene ChrX:3106627-3142991 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032900
 protein coding gene ChrX:1988101-2021377 (+)
CAST/EiJ ENSTCUGG00005054094
 protein coding gene ChrX:2377942-2414284 (+)
CBA/J ENSMUSGG00210054614
 protein coding gene ChrX:2459664-2496028 (+)
DBA/2J ENSMUSGG00185057456
 protein coding gene ChrX:9076790-9113153 (+)
FVB/NJ ENSMUSGG00205054530
 protein coding gene ChrX:2453412-2489773 (+)
JF1/MsJ ENSUMUGG00000058164
 protein coding gene ChrX:22963240-22999586 (+)
LP/J ENSMUSGG00230055505
 protein coding gene ChrX:13597000-13633361 (+)
NOD/ShiLtJ ENSMUSGG00190054523
 protein coding gene ChrX:2433891-2470260 (+)
NZO/HlLtJ ENSMUSGG00225055416
 protein coding gene ChrX:18862520-18898882 (+)
PWK/PhJ ENSLUMGG00010054048
 protein coding gene ChrX:2423588-2459925 (+)
SPRET/EiJ ENSMSPG00010020656
 protein coding gene ChrX:2461597-2496166 (+)
WSB/EiJ ENSIUOGG00005054102
 protein coding gene ChrX:16057338-16093745 (-)



Homology
more
  • Human Ortholog
    OTUD5, OTU deubiquitinase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTUD5, OTU deubiquitinase 5
  • Synonyms
    DUBA, MCAND
  • Links
    NCBI Gene ID: 55593
    UniProt: Q96G74

  • Chr Location
    Xp11.23; chrX:48922024-48958386 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele exhibit abnormalities in developmental patterning and embryo turning. Mice homozygous for a conditional allele activated in T cells exhibit increased Th17 differentiation and susceptibility to injection with anti-CD3 antibodies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031154 Ensembl Gene Model | MGI Sequence Detail 35263 C57BL/6J ±  kb
    transcript ENSMUST00000115667 Ensembl | MGI Sequence Detail 2708 Not Applicable  
    polypeptide ENSMUSP00000111331 Ensembl | MGI Sequence Detail 571 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 3
      cDNA 17

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2147820, MGI:2147900, MGI:2148034
    References
    more
    • Summaries
      All 44
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:62168 Means GD, et al., A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Genomics. 2000 May 1;65(3):213-23
    • Latest
      J:376035 Zhao Y, et al., Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Nat Commun. 2024 Jun 27;15(1):5441
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory