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Btnl2 Gene Detail
Summary
  • Symbol
    Btnl2
  • Name
    butyrophilin-like 2
  • Synonyms
    BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859549
    NCBI Gene: 547431
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34573796-34588469 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859549
 protein coding gene Chr17:34573763-34588469 (+)
129S1/SvImJ ENSMUSG00200047869
 protein coding gene Chr17:30276933-30291608 (+)
A/J ENSMUSG00195033441
 protein coding gene Chr17:31143482-31158326 (+)
AKR/J ENSMUSG00220048625
 protein coding gene Chr17:30171112-30185957 (+)
BALB/cJ ENSMUSG00180034478
 protein coding gene Chr17:30527207-30541938 (+)
C3H/HeJ ENSMUSG00175053321
 protein coding gene Chr17:30057266-30072103 (+)
C57BL/6NJ ENSMUSG00215052513
 protein coding gene Chr17:30117107-30131782 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021456
 protein coding gene Chr17:31166449-31179672 (+)
CAST/EiJ ENSTCUG00005050276
 protein coding gene Chr17:31099855-31114576 (+)
CBA/J ENSMUSG00210044748
 protein coding gene Chr17:29879373-29894212 (+)
DBA/2J ENSMUSG00185054070
 protein coding gene Chr17:32546495-32561224 (+)
FVB/NJ ENSMUSG00205022468
 protein coding gene Chr17:30393917-30408681 (+)
JF1/MsJ ENSUMUG00000044080
 protein coding gene Chr17:31814055-31828843 (+)
LP/J ENSMUSG00230054113
 protein coding gene Chr17:33675238-33689911 (+)
NOD/ShiLtJ ENSMUSG00190052705
 protein coding gene Chr17:30025221-30039908 (+)
NZO/HlLtJ ENSMUSG00225050953
 protein coding gene Chr17:35709224-35723963 (+)
PWK/PhJ ENSLUMG00010046247
 protein coding gene Chr17:29662712-29677438 (+)
SPRET/EiJ ENSMSPG00010037926
 protein coding gene Chr17:30804305-30819001 (+)
WSB/EiJ ENSIUOG00005048372
 protein coding gene Chr17:30730947-30745662 (+)



Homology
more
  • Human Ortholog
    BTNL2, butyrophilin like 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTNL2, butyrophilin like 2
  • Synonyms
    BTL-II, BTN7, HSBLMHC1, SS2
  • Links
    NCBI Gene ID: 56244
    UniProt: Q9UIR0

  • Chr Location
    6p21.32; chr6:32393339-32407181 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human BTNL2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show large bowel inflammation, loss of colonic crypt architecture, increase in pro-inflammatory cytokines in colonic tissue and a decrease in gamma-delta T17 cells in the intestinal epithelial lymphocyte population.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    48
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024340 Ensembl Gene Model | MGI Sequence Detail 14674 C57BL/6J ±  kb
    transcript ENSMUST00000025198 Ensembl | MGI Sequence Detail 2566 Not Applicable  
    polypeptide ENSMUSP00000025198 Ensembl | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685161
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:61935 Stammers M, et al., BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics. 2000 Apr;51(4-5):373-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory