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Pla2g6 Gene Detail
Summary
  • Symbol
    Pla2g6
  • Name
    phospholipase A2, group VI
  • Synonyms
    iPLA2, iPLA2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859152
    NCBI Gene: 53357
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79170428-79212590 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1174 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859152
 protein coding gene Chr15:79170428-79212915 (-)
129S1/SvImJ ENSMUSG00200052861
 protein coding gene Chr15:76282590-76324677 (-)
A/J ENSMUSG00195048504
 protein coding gene Chr15:76224811-76267115 (-)
AKR/J ENSMUSG00220048851
 protein coding gene Chr15:76268205-76310518 (-)
BALB/cJ ENSMUSG00180048457
 protein coding gene Chr15:76101811-76144108 (-)
C3H/HeJ ENSMUSG00175046479
 protein coding gene Chr15:76413049-76455347 (-)
C57BL/6NJ ENSMUSG00215052635
 protein coding gene Chr15:76180784-76222949 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020011
 protein coding gene Chr15:73284542-73327132 (-)
CAST/EiJ ENSTCUG00005038349
 protein coding gene Chr15:75724862-75767053 (-)
CBA/J ENSMUSG00210036299
 protein coding gene Chr15:76188201-76230497 (-)
DBA/2J ENSMUSG00185039202
 protein coding gene Chr15:76198078-76240376 (-)
FVB/NJ ENSMUSG00205022222
 protein coding gene Chr15:75917912-75960219 (-)
JF1/MsJ ENSUMUG00000050934
 protein coding gene Chr15:75776299-75819219 (-)
LP/J ENSMUSG00230051463
 protein coding gene Chr15:79530944-79574616 (-)
NOD/ShiLtJ ENSMUSG00190036322
 protein coding gene Chr15:76208468-76250553 (-)
NZO/HlLtJ ENSMUSG00225051808
 protein coding gene Chr15:79860317-79902655 (-)
PWK/PhJ ENSLUMG00010051847
 protein coding gene Chr15:75996206-76039062 (-)
SPRET/EiJ ENSMSPG00010049700
 protein coding gene Chr15:77660968-77700788 (-)
WSB/EiJ ENSIUOG00005038542
 protein coding gene Chr15:76264635-76306974 (-)



Homology
more
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G6, phospholipase A2 group VI
  • Synonyms
    CaI-PLA2, GVI, INAD1, iPLA2, iPLA2beta, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9
  • Links
    NCBI Gene ID: 8398
    UniProt: O60733

  • Chr Location
    22q13.1; chr22:38111495-38214778 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Pla2g6 mouse models; 6 with human PLA2G6 associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 8 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display impaired male fertility and asthenozoospermia. Mice homozygous for a second null allele display increased susceptibility to induced kidney damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    695
  • Tissues
    98
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042632 Ensembl Gene Model | MGI Sequence Detail 42163 C57BL/6J ±  kb
    transcript ENSMUST00000174021 Ensembl | MGI Sequence Detail 3318 Not Applicable  
    polypeptide ENSMUSP00000134672 Ensembl | MGI Sequence Detail 807 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2146260
    References
    more
    • Summaries
      All 160
      Developmental Gene Expression 2
      Diseases 6
      Gene Ontology 15
      Phenotypes 89
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory