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Cnot4 Gene Detail
Summary
  • Symbol
    Cnot4
  • Name
    CCR4-NOT transcription complex, subunit 4
  • Synonyms
    Not4, Not4h, Not4hp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859026
    NCBI Gene: 53621
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34999000-35110646 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.20 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    465 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859026
 protein coding gene Chr6:34999000-35110659 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030568
 protein coding gene Chr6:33144425-33262089 (-)
A/J MGP_AJ_G0030541
 protein coding gene Chr6:31713500-31825130 (-)
AKR/J MGP_AKRJ_G0030468
 protein coding gene Chr6:32789553-32903517 (-)
BALB/cJ MGP_BALBcJ_G0030551
 protein coding gene Chr6:31896124-32009223 (-)
C3H/HeJ MGP_C3HHeJ_G0030264
 protein coding gene Chr6:32744933-32862231 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031005
 protein coding gene Chr6:33977368-34093931 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028217
 protein coding gene Chr6:29803251-29914363 (-)
CAST/EiJ MGP_CASTEiJ_G0029666
 protein coding gene Chr6:32571623-32693093 (-)
CBA/J MGP_CBAJ_G0030242
 protein coding gene Chr6:35294891-35416901 (-)
DBA/2J MGP_DBA2J_G0030386
 protein coding gene Chr6:31592544-31705214 (-)
FVB/NJ MGP_FVBNJ_G0030340
 protein coding gene Chr6:31385563-31501077 (-)
LP/J MGP_LPJ_G0030473
 protein coding gene Chr6:33249785-33368959 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030376
 protein coding gene Chr6:37596238-37722235 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031035
 protein coding gene Chr6:32667271-32781943 (-)
PWK/PhJ MGP_PWKPhJ_G0029380
 protein coding gene Chr6:31218834-31334860 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029216
 protein coding gene Chr6:32352772-32468200 (-)
WSB/EiJ MGP_WSBEiJ_G0029742
 protein coding gene Chr6:32611276-32727200 (-)



Homology
more
  • Human Ortholog
    CNOT4, CCR4-NOT transcription complex subunit 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT4, CCR4-NOT transcription complex subunit 4
  • Synonyms
    CLONE243, NOT4, NOT4H
  • Links
    NCBI Gene ID: 4850
    neXtProt AC: NX_O95628
    UniProt: O95628

  • Chr Location
    7q33; chr7:135361795-135510145 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal placental and chorion formation and complete lethality throughout fetal growth and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    139
  • cDNA Data
    18
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53621 NCBI Gene Model | MGI Sequence Detail 111647 C57BL/6J ±  kb
    transcript NM_001410682 RefSeq | MGI Sequence Detail 4579 C57BL/6  
    polypeptide Q8BT14 UniProt | EBI | MGI Sequence Detail 575 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:69146 Hwang SY, et al., Expression of genes involved in mammalian meiosis during the transition from egg to embryo. Mol Reprod Dev. 2001 Jun;59(2):144-58
    • Latest
      J:307645 Dai XX, et al., The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis. Adv Sci (Weinh). 2021 May;8(10):2003636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory