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Atf7ip Gene Detail
Summary
  • Symbol
    Atf7ip
  • Name
    activating transcription factor 7 interacting protein
  • Synonyms
    2610204M12Rik, AM, ATFa-associated Modulator, Mcaf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858965
    NCBI Gene: 54343
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:136495787-136587848 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 66.59 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2352 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858965
 protein coding gene Chr6:136483165-136587860 (+)
129S1/SvImJ ENSMUSG00200029878
 protein coding gene Chr6:134064410-134064739 (+)
129S1/SvImJ ENSMUSGG00200054744
 protein coding gene Chr6:134069688-134087038 (+)
A/J ENSMUSGG00195055244
 protein coding gene Chr6:132912053-132929403 (+)
A/J ENSMUSG00195007568
 protein coding gene Chr6:132906773-132907102 (+)
AKR/J ENSMUSG00220033829
 protein coding gene Chr6:131134877-131135206 (+)
AKR/J ENSMUSGG00220054774
 protein coding gene Chr6:131140157-131157506 (+)
BALB/cJ ENSMUSGG00180055358
 protein coding gene Chr6:133024016-133041414 (+)
BALB/cJ ENSMUSG00180017037
 protein coding gene Chr6:133018769-133019098 (+)
C3H/HeJ ENSMUSGG00175054903
 protein coding gene Chr6:132932252-132949601 (+)
C3H/HeJ ENSMUSG00175030148
 protein coding gene Chr6:132926972-132927301 (+)
C57BL/6NJ ENSMUSG00215016498
 protein coding gene Chr6:133172669-133172998 (+)
C57BL/6NJ ENSMUSGG00215055568
 protein coding gene Chr6:133177924-133195376 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028996
 protein coding gene Chr6:134529628-134621233 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210004117
 protein coding gene Chr6:132979286-132979615 (+)
CBA/J ENSMUSGG00210054852
 protein coding gene Chr6:132984566-133001915 (+)
DBA/2J ENSMUSGG00185057738
 protein coding gene Chr6:133646862-133664213 (+)
DBA/2J ENSMUSG00185020961
 protein coding gene Chr6:133641582-133641911 (+)
FVB/NJ ENSMUSGG00205054322
 protein coding gene Chr6:132139516-132156880 (+)
FVB/NJ ENSMUSG00205026814
 protein coding gene Chr6:132134222-132134551 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055655
 protein coding gene Chr6:134866126-134883476 (+)
LP/J ENSMUSG00230009014
 protein coding gene Chr6:134860848-134861177 (+)
NOD/ShiLtJ ENSMUSGG00190054835
 protein coding gene Chr6:133485087-133502436 (+)
NOD/ShiLtJ ENSMUSG00190006096
 protein coding gene Chr6:133479807-133480136 (+)
NZO/HlLtJ ENSMUSG00225007136
 protein coding gene Chr6:137640838-137734191 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010034512
 protein coding gene Chr6:135303016-135377839 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ATF7IP, activating transcription factor 7 interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF7IP, activating transcription factor 7 interacting protein
  • Synonyms
    AM, ATF7IP1, ATF-IP, MCAF, MCAF1, p621
  • Links
    NCBI Gene ID: 55729
    UniProt: Q6VMQ6

  • Chr Location
    12p13.1; chr12:14365627-14502931 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    669
  • Tissues
    71
  • cDNA Data
    25
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54343 NCBI Gene Model | MGI Sequence Detail 92062 C57BL/6J ±  kb
transcript NM_001388195 RefSeq | MGI Sequence Detail 8667 ZRU/MplStud  
polypeptide Q7TT18 UniProt | EBI | MGI Sequence Detail 1306 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000004405 activating transcription factor 7-interacting protein 1
    (term hierarchy)
  • InterPro Domains
    IPR026085 Activating transcription factor 7-interacting protein
    IPR056565 Activating transcription factor 7-interacting protein, Fn3 domain
    IPR031870 ATF7-interacting protein , protein binding domain
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
  • GlyGen
    Q7TT18 29 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (28 sites)
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1919738
References
more
  • Summaries
    All 50
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:61657 De Graeve F, et al., A murine ATFa-associated factor with transcriptional repressing activity. Oncogene. 2000 Mar 30;19(14):1807-19
  • Latest
    J:381085 Kabir M, et al., A machine learning classifier to identify and prioritise genes associated with murine cardiac development. PLoS Genet. 2026 Feb;22(2):e1011489
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory