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Nxf1 Gene Detail
Summary
  • Symbol
    Nxf1
  • Name
    nuclear RNA export factor 1
  • Synonyms
    Mex67, Mvb1, TAP, Tip associated protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858330
    NCBI Gene: 53319
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8734467-8748274 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.50 cM, cytoband A
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858330
 protein coding gene Chr19:8734437-8748286 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024807
 protein coding gene Chr19:6030819-6048883 (+)
A/J MGP_AJ_G0024775
 protein coding gene Chr19:5709049-5724473 (+)
AKR/J MGP_AKRJ_G0024750
 protein coding gene Chr19:5797380-5812618 (+)
BALB/cJ MGP_BALBcJ_G0024775
 protein coding gene Chr19:5813282-5829207 (+)
C3H/HeJ MGP_C3HHeJ_G0024541
 protein coding gene Chr19:5878230-5893617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025222
 protein coding gene Chr19:6149992-6170134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022651
 protein coding gene Chr19:5952928-5969090 (+)
CAST/EiJ MGP_CASTEiJ_G0024014
 protein coding gene Chr19:5526642-5544952 (+)
CBA/J MGP_CBAJ_G0024515
 protein coding gene Chr19:6270148-6288623 (+)
DBA/2J MGP_DBA2J_G0024642
 protein coding gene Chr19:5539690-5556003 (+)
FVB/NJ MGP_FVBNJ_G0024609
 protein coding gene Chr19:5614916-5630133 (+)
LP/J MGP_LPJ_G0024729
 protein coding gene Chr19:5919959-5937426 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024636
 protein coding gene Chr19:6135623-6153198 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025271
 protein coding gene Chr19:5842181-5857598 (+)
PWK/PhJ MGP_PWKPhJ_G0023759
 protein coding gene Chr19:5205352-5224426 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0024076
 protein coding gene Chr19:5809229-5825311 (+)



Homology
more
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NXF1, nuclear RNA export factor 1
  • Synonyms
    MEX67, TAP
  • Links
    NCBI Gene ID: 10482
    neXtProt AC: NX_Q9UBU9
    UniProt: Q9UBU9

  • Chr Location
    11q12.3; chr11:62792123-62806302 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    10 phenotype references
Mice homozygous for some alleles are able to suppress defects caused by retrovirus insertion mutations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    33
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 53319 NCBI Gene Model | MGI Sequence Detail 13808 C57BL/6J ±  kb
transcript NM_001276704 RefSeq | MGI Sequence Detail 4035 ZRU/MplStud  
polypeptide Q99JX7 UniProt | EBI | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1194888
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory