About   Help   FAQ
Zranb2 Gene Detail
Summary
  • Symbol
    Zranb2
  • Name
    zinc finger, RAN-binding domain containing 2
  • Synonyms
    Zfp265, Zis, Znf265
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858211
    NCBI Gene: 53861
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:157239797-157254047 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 81.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    287 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858211
 protein coding gene Chr3:157239749-157254047 (+)
129S1/SvImJ ENSMUSG00200000075
 protein coding gene Chr3:154236488-154250744 (+)
A/J ENSMUSG00195002651
 protein coding gene Chr3:154363377-154377567 (+)
AKR/J ENSMUSG00220010827
 protein coding gene Chr3:152783294-152797487 (+)
BALB/cJ ENSMUSG00180006564
 protein coding gene Chr3:154215089-154229280 (+)
C3H/HeJ ENSMUSG00175003264
 protein coding gene Chr3:153831604-153845794 (+)
C57BL/6NJ ENSMUSG00215004219
 protein coding gene Chr3:154446590-154460846 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025763
 protein coding gene Chr3:150406877-150420980 (+)
CAST/EiJ ENSTCUG00005000045
 protein coding gene Chr3:154873608-154887835 (+)
CBA/J ENSMUSG00210000348
 protein coding gene Chr3:154461833-154476024 (+)
DBA/2J ENSMUSG00185000039
 protein coding gene Chr3:155112492-155126684 (+)
FVB/NJ ENSMUSG00205008607
 protein coding gene Chr3:153374759-153388950 (+)
JF1/MsJ ENSUMUG00000000053
 protein coding gene Chr3:153860785-153875253 (+)
LP/J ENSMUSG00230009334
 protein coding gene Chr3:156985388-156999640 (+)
NOD/ShiLtJ ENSMUSG00190007456
 protein coding gene Chr3:155464933-155479123 (+)
NZO/HlLtJ ENSMUSG00225005745
 protein coding gene Chr3:159506921-159521111 (+)
PWK/PhJ ENSLUMG00010000048
 protein coding gene Chr3:153799849-153814093 (+)
SPRET/EiJ ENSMSPG00010000285
 protein coding gene Chr3:155161053-155175344 (+)
WSB/EiJ ENSIUOG00005003361
 protein coding gene Chr3:154600388-154614633 (+)



Homology
more
  • Human Ortholog
    ZRANB2, zinc finger RANBP2-type containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZRANB2, zinc finger RANBP2-type containing 2
  • Synonyms
    ZIS, ZIS1, ZIS2, ZNF265
  • Links
    NCBI Gene ID: 9406
    UniProt: O95218

  • Chr Location
    1p31.1; chr1:71063251-71081289 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    31
  • cDNA Data
    25
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028180 Ensembl Gene Model | MGI Sequence Detail 14251 C57BL/6J ±  kb
    transcript ENSMUST00000106058 Ensembl | MGI Sequence Detail 2924 Not Applicable  
    polypeptide ENSMUSP00000101673 Ensembl | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000018217 zinc finger Ran-binding domain-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR017337 Zinc finger Ran-binding domain-containing protein 2
      IPR001876 Zinc finger, RanBP2-type
      IPR036443 Zinc finger, RanBP2-type superfamily
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139650
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:61526 Adams DJ, et al., Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene. Cytogenet Cell Genet. 2000;88(1-2):68-73
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory