Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Ccl3tm1Unc Name: C-C motif chemokine ligand 3; targeted mutation 1, University of North Carolina MGI ID: MGI:1857243 Synonyms: CCL3-, MIP-1alpha -, Scya3 -, Scya3tm1Coo Gene: Ccl3  Location: Chr11:83538670-83540181 bp, - strand  Genetic Position: Chr11, 51.04 cM Alliance: Ccl3tm1Unc page

Hexbtm1Rlp/Hexbtm1Rlp mice exhibit Sandhoff disease phenotypes that are improved in Hexbtm1Rlp/Hexbtm1Rlp Ccl3tm1Unc/Ccl3tm1Unc mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:28704
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette was used to delete a region including 300 nucleotides of the 5' untranslated region, all of exon 1, and a portion of exon 2. An absence of transcript was observed via Northern blot analysis of total mRNA derived from bone marrow macrophages isolated from homozygous mutant animals. (J:28704)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl3 Mutation:	13 strains or lines available

Original:	J:28704 Cook DN, et al., Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science. 1995 Sep 15;269(5230):1583-5
All:	72 reference(s)