Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Inhbbtm1Jae
Name:	inhibin beta-B; targeted mutation 1, Rudolf Jaenisch
MGI ID:	MGI:1857203
Synonyms:	bb1, bb2, Inhbb-
Gene:	Inhbb  Location: Chr1:119343195-119349978 bp, - strand  Genetic Position: Chr1, 52.29 cM
Alliance:	Inhbbtm1Jae page

Germline Transmission:	Earliest citation of germline transmission: J:16995
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 1.3 kb region of the gene, which spanned the translational start codon, the signal peptide coding region, and most of exon 1 of the gene. In the construct designated bb1, the neomycin cassette was inserted in the same transcriptional orientation as the gene; in the construct designated bb2, the neomycin cassette was inserted in the reverse orientation. (J:16995)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	28 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Inhbbtm1Jae

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Inhbb Mutation:	24 strains or lines available

Original:	J:16995 Vassalli A, et al., Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 1994 Feb 15;8(4):414-27
All:	23 reference(s)