Analysis Tools
muscle
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• increased triceps weight in males
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• increased weight in males and females
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Allele Symbol Allele Name Allele ID |
Inhbbtm1Jae targeted mutation 1, Rudolf Jaenisch MGI:1857203 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased triceps weight in males
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• increased weight in males and females
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in some females initiation of labor fails resulting in the death of the female and fetuses in utero
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• Background Sensitivity: at weaning fewer than expected mice survive on a 129S4/SvJae BALB/c background compared to on a 124S4/SvJae C57BL/6 background with both exhibiting decreased survival relative to wild-type mice
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• most females deliver on E20.5 and some on E21.5 instead of E19.5 as wild-type females do
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• female mice have a reduced ability to produce live offspring regardless of genotype to which they are mated
• female mice give birth to normal sized litters that die within the first day after birth regardless of genotype
• Background Sensitivity: female mice with the 129S4/SvJae BALB/c background are most severely affected
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• increased inflammation of the cornea and eyelids is observed on the first day after birth in mice with open eyelids
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• ocular dystrophy is observed in mice whose eyelids were delayed in opening
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• hyperkeratinization and squamous metaplasia of the corneal epithelium is observed during the first day after birth in mice with open eyelids
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• corneal opacification is observed in mice whose eyelids were delayed in opening
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• eyelids that were open at birth and subsequently resealed exhibit a delay in reopening
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• some mice have open eye lids at birth but seal in subsequent days
• Background Sensitivity: fewer mice on the 129S4/SvJae BALB/c background had open eyelids at birth compared to on the 129S4/SvJae C57BL/6 background and no mice on an inbred 129S4/SvJae background had open eyelids at birth
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• serum follicle stimulating hormone levels are increased by about 20% relative to in heterozygotes
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• maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive
• milk accumulates in the mammary tissue at day 0.5 after delivery
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• at 0.5 days after delivery there is an increase in the glandular to adipose tissue ratio
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• at 0.5 days after delivery, vacuolation of the lobules of the mammary gland is observed
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• increased inflammation of the cornea and eyelids is observed on the first day after birth in mice with open eyelids
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• maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive
• milk accumulates in the mammary tissue at day 0.5 after delivery
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• at 0.5 days after delivery there is an increase in the glandular to adipose tissue ratio
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• at 0.5 days after delivery, vacuolation of the lobules of the mammary gland is observed
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• maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive
• milk accumulates in the mammary tissue at day 0.5 after delivery
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 2 of 4 females produce no oocytes upon superovulation
• however, there is no difference in the number of oocytes superovulated in the remaining 2 mice
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• 2 of 4 females produce no oocytes upon superovulation
• however, there is no difference in the number of oocytes superovulated in the remaining 2 mice
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• at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhbatm1Zuk/Inhbatm3Zuk mice
• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
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• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhbatm1Zuk/Inhbatm3Zuk mice
• at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present
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• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhbatm1Zuk/Inhbatm3Zuk mice
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• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker
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• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhbatm1Zuk/Inhbatm3Zuk mice)
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• females are infertile
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• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker
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• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhbatm1Zuk/Inhbatm3Zuk mice)
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• at 6 weeks, 8 to 11 weeks, and 3 months of age, the number of corpus luteums is increased compared to Inhbatm1Zuk/Inhbatm3Zuk mice
• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
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• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhbatm1Zuk/Inhbatm3Zuk mice
• at 8 months, follicles with lutenizing granulosa cells and multiple fluid-filled or hemorrhagic cysts are present
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• between 8 and 11 weeks, the number of antral follicles is decreased compared to Inhbatm1Zuk/Inhbatm3Zuk mice
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• at 8 months, multiple fluid-filled or hemorrhagic cysts are present that are positive for a granulose cell marker but not an epithelial marker
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• by 8 months, the mass of the ovaries has increased 6-fold (31.5+/-2.9 mg compared to 5.2+/-2.9 mg in Inhbatm1Zuk/Inhbatm3Zuk mice)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
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• 3 of 11 females are infertile
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• the number of litters produced by females is reduced 43% (0.08+/-0.08 litters per month compared 0.89+/-0.04 litters per month in Inhbatm1Zuk/Inhbatm3Zuk mice)
• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhbatm1Zuk/Inhbatm3Zuk females
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• the number of pups per litter is decreased 33% relative (.80+/-0.49 pups per litter compared to 7.78+/-0.48 pups per litter in Inhbatm1Zuk/Inhbatm3Zuk mice)
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• beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
• the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhbatm1Zuk/Inhbatm3Zuk mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 3 of 9 mice (33%) die from cleft secondary palates
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• 3 of 9 mice (33%) die from cleft secondary palates
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• 3 of 9 mice (33%) die from cleft secondary palates
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• 3 of 9 mice (33%) die from cleft secondary palates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 3 of 5 females are infertile
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• the number of litters produced by females is reduced 43% (0.10+/-0.07 litters per month compared 0.89+/-0.04 litters per month in Inhbatm1Zuk/Inhbatm3Zuk mice)
• however, there is no difference in the number of oocytes produced upon superovulation compared to Inhbatm1Zuk/Inhbatm3Zuk females
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• the number of pups per litter is decreased 33% relative (1.00+/-0.63 pups per litter compared to 7.78+/-0.48 pups per litter in Inhbatm1Zuk/Inhbatm3Zuk mice)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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