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Pcdh12 Gene Detail
Summary
  • Symbol
    Pcdh12
  • Name
    protocadherin 12
  • Synonyms
    vascular endothelial cadherin-2, VE-cadherin-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855700
    NCBI Gene: 53601
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:38400145-38417454 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 20.17 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855700
protein coding gene Chr18:38400142-38417455 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024361
protein coding gene Chr18:36707472-36725447 (-)
A/J MGP_AJ_G0024328
protein coding gene Chr18:35439691-35461863 (-)
AKR/J MGP_AKRJ_G0024297
protein coding gene Chr18:36401859-36418862 (-)
BALB/cJ MGP_BALBcJ_G0024328
protein coding gene Chr18:35504482-35521466 (-)
C3H/HeJ MGP_C3HHeJ_G0024094
protein coding gene Chr18:36475809-36493101 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024770
protein coding gene Chr18:38011646-38030099 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022209
protein coding gene Chr18:35458500-35475795 (-)
CAST/EiJ MGP_CASTEiJ_G0023569
protein coding gene Chr18:36431076-36448544 (-)
CBA/J MGP_CBAJ_G0024064
protein coding gene Chr18:39135955-39152964 (-)
DBA/2J MGP_DBA2J_G0024194
protein coding gene Chr18:35037863-35054942 (-)
FVB/NJ MGP_FVBNJ_G0024160
protein coding gene Chr18:34759952-34777292 (-)
LP/J MGP_LPJ_G0024278
protein coding gene Chr18:36769777-36786814 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024191
protein coding gene Chr18:40383305-40403028 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024819
protein coding gene Chr18:36278293-36295614 (-)
PWK/PhJ MGP_PWKPhJ_G0023313
protein coding gene Chr18:35264410-35282322 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023118
protein coding gene Chr18:36490687-36508070 (-)
WSB/EiJ MGP_WSBEiJ_G0023632
protein coding gene Chr18:36175878-36197158 (-)



Homology
more
  • Human Ortholog
    PCDH12, protocadherin 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCDH12, protocadherin 12
  • Synonyms
    DMJDS1, VECAD2, VE-cadherin-2
  • Links
    NCBI Gene ID: 51294
    neXtProt AC: NX_Q9NPG4
    UniProt: Q9NPG4

  • Chr Location
    5q31.3; chr5:141943581-141969741 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation are viable, fertile and do not display any obvious histomorphological abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53601 NCBI Gene Model | MGI Sequence Detail 17310 C57BL/6J ±  kb
    transcript NM_017378 RefSeq | MGI Sequence Detail 5587 C57BL/6  
    polypeptide O55134 UniProt | EBI | MGI Sequence Detail 1180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 34
      Primer pair 4
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 35
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:48727 Telo' P, et al., Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells. J Biol Chem. 1998 Jul 10;273(28):17565-72
    • Latest
      J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory